CD55 - CD55 molecule (Cromer blood group) Gene
Also Known as CR; TC; DAF; CROM; CHAPLE
Species: Homo sapiens
About CD55
This gene has 23 transcripts (splice variants), 95 orthologues, 39 paralogues and is associated with 3 phenotypes. Broad expression in lung (RPKM 90.6), adrenal (RPKM 63.8) and 23 other tissues.
Summary
This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]
CD55 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_000574.5 | NP_000565.1 | complement decay-accelerating factor isoform 1 preproprotein |
| NM_001114752.3 | NP_001108224.1 | complement decay-accelerating factor isoform 2 precursor |
| NM_001300902.2 | NP_001287831.1 | complement decay-accelerating factor isoform 5 precursor |
| NM_001300903.2 | NP_001287832.1 | complement decay-accelerating factor isoform 6 precursor |
| NM_001300904.2 | NP_001287833.1 | complement decay-accelerating factor isoform 7 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables lipid binding |
IDA
IDA: Inferred from direct assay
|
12731067 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9064337 | GOA |
| enables virus receptor activity |
IDA
IDA: Inferred from direct assay
|
7525274 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
15907827 | GOA |
| located in membrane raft |
IDA
IDA: Inferred from direct assay
|
11313396 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
6211481 | GOA |
CD55 Protein Structure
Sushi: Sushi repeat (SCR repeat) (36 - 89)
Sushi: Sushi repeat (SCR repeat) (98 - 154)
Sushi: Sushi repeat (SCR repeat) (163 - 220)
Sushi: Sushi repeat (SCR repeat) (225 - 283)
- 0
- 100
- 200
- 300
- 381 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
complement decay-accelerating factor |
|
CD55 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CD55 | P08174 | ADGRE5 | Homo sapiens | P48960 | 11297558 |
Recombinant CD55 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72721 | CD55/DAF Protein, Human (HEK293, His) | P08174 (D35-S353) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P75394 | CD55/DAF Protein, Human (HEK293, hFc) | P08174 (D35-S353) | ≥ 90%, as determined by reducing SDS-PAGE. |
CD55 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P82695 | CD55 Antibody (YA2440) | WB | Human |
| HY-P82695A | CD55 Antibody (YA2440)(PBS only) | WB | Human |
| HY-P84002 | CD55 Antibody (YA3699) | WB, FC, ELISA | Human |
| HY-P84002A | CD55 Antibody (YA3699)(PBS only) | WB, FC, ELISA | Human |
| HY-P84997 | CD55 Antibody (YA4689) | ELISA, FC | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy |
|
|
| Blood Group, Cromer System |
|
|
| Protein-Losing Enteropathy |
|
|
| Paroxysmal Nocturnal Hemoglobinuria |
|
|
| Hemoglobinuria |
|
|
| Primary Intestinal Lymphangiectasia |
|
|
| Myocarditis |
|
|
| Congenital Dyserythropoietic Anemia |
|
|
| Thrombosis |
|
|
| Plasmodium Falciparum Malaria |
|
|
| Anemia, Autoimmune Hemolytic |
|
|
| Aplastic Anemia |
|
|
| Lymphopenia |
|
|
| Hemolytic Anemia |
|
|
| Hemolytic-Uremic Syndrome |
|
|
| Myasthenia Gravis |
|
|
| Acute Hemorrhagic Conjunctivitis |
|
|
| Complement Component 3 Deficiency |
|
|
| Meningitis |
|
|
| Glomerulonephritis |
|
|
| Follicular Lymphoma |
|
|
| Burkitt Lymphoma |
|
|
| Complement Component 5 Deficiency |
|
|
| Pancytopenia |
|
|
| Rhabdomyosarcoma |
|
|
| Malaria |
|
|
| Acute Flaccid Myelitis |
|
|
| Hemolytic Uremic Syndrome, Atypical 1 |
|
|
| Complement Deficiency |
|
|
| Hantavirus Hemorrhagic Fever With Renal Syndrome |
|
|
| Systemic Lupus Erythematosus |
|
|
| Myelodysplastic Syndrome |
|
|
| Monkeypox |
|
|
| Beta-Thalassemia |
|
|
| Developmental And Epileptic Encephalopathy 38 |
|
|
| Autoimmune Disease |
|
|
| Vulvar Angiokeratoma |
|
|
| Deficiency Anemia |
|
|
| Chronic Pyelonephritis |
|
|
| Macular Degeneration, Age-Related, 1 |
|
|
| Membranoproliferative Glomerulonephritis |
|
|
| Budd-Chiari Syndrome |
|
|
| Iga Glomerulonephritis |
|
|
| Hereditary Angioedema |
|
|
| Colorectal Cancer |
|
|
| Esophageal Cancer |
|
|
| Myocardial Infarction |
|
|
| Melanoma, Uveal |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | CD55 | VGNC | VGNC:53335 |
| Rattus norvegicus | CD55 | RGD | RGD:620651 |
| Macaca mulatta | CD55 | VGNC | VGNC:99865 |
| Others | CD55 | NCBI |