CD55 Antibody (YA4689)

Cat. No.: HY-P84997: Ficha de datos User Guide for Antibodies
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CD55 Antibody (YA4689) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD55.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn
Referencias

Descripciòn

CD55 Antibody (YA4689) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CD55.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human

SwissProt ID

P08174

Gene ID

1604 [NCBI]

Immunogen

Purified recombinant Human CD55

Application &
Dilution Ratio

Application	Dilution Ratio
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-100000
FC FC: Flow Cytometry	1-2μg/Test

Pureza	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in Phosphate-buffered solution.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829); (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5; (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable); (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21

Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Cell membrane; Lipid-anchor, GPI-anchor; Secreted; Secreted; Secreted; Cell membrane; Lipid-anchor, GPI-anchor; Cell membrane; Lipid-anchor, GPI-anchor

Expression：
Tissue_specificity:This molecule is expressed on the plasma membrane of all cell types that are in close contact with plasma complement proteins. It is also present on the surface of extracellular interstitial epithelial cells, and variants of this molecule are found in body fluids and the extracellular matrix.

Isoforms & Post-Translational Modification：P08174 has 7 isomers: P08174-1: 41400 Da (predicted); P08174-2: 48717 Da (predicted); P08174-3: 41900 Da (predicted); P08174-4: 39759 Da (predicted); P08174-5: 48513 Da (predicted); P08174-6: 56218 Da (predicted); P08174-7: 59038 Da (predicted).
The Ser/Thr-rich domain is heavily O-glycosylated

Subunit：Monomer (major form) and non-disulfide-linked, covalent homodimer (minor form). Interacts with ADGRE5 (PubMed:11297558)

Synonyms

CD55; CR; DAF; Complement decay-accelerating factor; CD55; CD55 nanobody;

Documentación

User Guide for Antibodies (1077 KB)

Referencias

[1]. /biology-dictionary/jurkat-cell.html [Content Brief]