CEP164 Antibody (YA8913)
(Synonyms: KIAA1052, NPHP15, CEP164, Centrosomal protein of 164 kDa, Cep164)
Based on 1 Customer Validation
CEP164 Antibody (YA8913) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CEP164.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, ICC/IF, IF-Tissue, IP, ELISA
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Reactivity :
human
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IP
IP: Immunoprecipitation
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:100-1000 | 1:50-500 | 1:50-500 | 1-2μg per 100-500μg Total protein | 1:30-3000 |
Product Details
CEP164 Antibody (YA8913) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CEP164.
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Host Mouse
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Species Reactivityhuman
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Calculated Molecular Weight Predicted band size: 164 kDa
A synthesized peptide derived from human CEP164.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
CEP164 plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1
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Subcellular Localization
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole; Nucleus
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Expression
Tissue_Specificity: Expressed in several cell lines. -
Isoforms & Post-Translational Modification
CEP164 has 2 isoforms, Q9UPV0-1: amino acid length is 1460, molecular weight is 164314 Da (predicted); Q9UPV0-2: amino acid length is 1455, molecular weight is 163544 Da (predicted).
Phosphorylation at Ser-186 is induced upon DNA-damage caused by treatment with IR irradiation, UV irradiation, hydroxyurea or amphidicolin. Also MDC1-mediated chromatin remodeling is critical for DNA damage-induced phosphorylation -
Subunit
Interacts (via N-terminus) with ATRIP.
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SwissProt ID
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Synonyms
KIAA1052, NPHP15, CEP164, Centrosomal protein of 164 kDa, Cep164
Documentation
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