country

Change Language

Country or Region:

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P87906

CHD4 Antibody (YA7591)

CHD4 Antibody (YA7591) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to CHD4.

For research use only. We do not sell to patients.

Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence	ELISA ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio	1:2000-1:10000	1:200-1:1000	1:5000-1:20000

Description

CHD4 Antibody (YA7591) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to CHD4.

Host Rabbit
Clonality Monoclonal,Recombinant
Species Reactivity
Human, Mouse
Observed Molecular Weight

Observed band size: 260 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 218 kDa

Immunogen

The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

Protein A affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG, Kappa

Appearance

Liquid
Formulation

Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

CHD4 is an ATP-dependent chromatin-remodeling factor that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis^[1]^[2]^[3]^[4]^[5]^[6].
Subcellular Localization

Nucleus,Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Expression

Tissue_Specificity: Widely expressed
Isoforms & Post-Translational Modification

Q14839 has two isomers: Q14839-1: 218005 Da (predicted); Q14839-2: 220848 Da (predicted).
Subunit

Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:10204490, PubMed:15454082, PubMed:16428440, PubMed:28977666, PubMed:33283408, PubMed:9804427)
SwissProt ID

Q14839