ChemR23 Antibody
(Synonyms: CHEMR23, DEZ, CMKLR1, Chemerin-like receptor 1, Chemokine-like receptor 1, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ)ChemR23 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ChemR23.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
ChemR23 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to ChemR23.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
Synthetic peptide corresponding to the center region of human CMKLR1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ChemR23 is a Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism[1].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Prominently expressed in developing osseous and cartilaginous tissue. Also found in adult parathyroid glands. Expressed in cardiovascular system, brain, kidney, gastrointestinal tissues and myeloid tissues. Expressed in a broad array of tissues associated with hematopoietic and immune function including, spleen, thymus, appendix, lymph node, bone marrow and fetal liver. Among leukocyte populations abundant expression in monocyte-derived macrophage and immature dendritic cells (DCs). High expression in blood monocytes and low levels in polymorphonuclear cells and T-cells. Expressed on endothelial cells. Highly expressed in differentiating adipocytes.
Induction: Up-regulated by inflammatory cytokines TNF and IFN-gamma in monocytes. Up-regulated by TNF, IL-1-beta and IL-6 in endothelial cells. -
Isoforms & Post-Translational Modification
ChemR23 has 2 isoforms, Q99788-1: amino acid length is 373, molecular weight is 42322 Da (predicted); Q99788-2: amino acid length is 371, molecular weight is 42035 Da (predicted).
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SwissProt ID
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Synonyms
CHEMR23, DEZ, CMKLR1, Chemerin-like receptor 1, Chemokine-like receptor 1, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ
Documentation
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