CMKLR1 - chemerin chemokine-like receptor 1 Gene

Also Known as DEZ; RVER1; ChemR23; CHEMERINR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1240

About CMKLR1

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:108,288,046-108,339,311 (from NCBI)

This gene has 6 transcripts (splice variants), 333 orthologues and 8 paralogues. Broad expression in spleen (RPKM 14.3), placenta (RPKM 10.1) and 22 other tissues.

Summary

Enables adipokinetic hormone binding activity and adipokinetic hormone receptor activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; positive regulation of macrophage chemotaxis; and regulation of calcium-mediated signaling. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

CMKLR1 Products (4)

mRNA Protein Name
NM_001142343.2 NP_001135815.1 chemerin-like receptor 1 isoform a
NM_001142344.2 NP_001135816.1 chemerin-like receptor 1 isoform a
NM_001142345.2 NP_001135817.1 chemerin-like receptor 1 isoform a
NM_004072.3 NP_004063.1 chemerin-like receptor 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adipokinetic hormone binding IDA
IDA: Inferred from direct assay
27716822 GOA
enables adipokinetic hormone receptor activity IDA
IDA: Inferred from direct assay
27716822 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
14530373 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
14530373 GOA
involved in chemotaxis IDA
IDA: Inferred from direct assay
14530373 GOA
involved in negative regulation of NF-kappaB transcription factor activity IDA
IDA: Inferred from direct assay
15753205 GOA
involved in positive regulation of macrophage chemotaxis IMP
IMP: Inferred from mutant phenotype
19443732 GOA
involved in regulation of calcium-mediated signaling IDA
IDA: Inferred from direct assay
14530373 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
14530373 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

chemerin-like receptor 1

  • G-protein coupled receptor ChemR23

CMKLR1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810859 ChemR23 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Monckeberg Arteriosclerosis

  • Monckeberg Medial Calcific Sclerosis
Cardiovascular Syphilis

  • Syphilis, Cardiovascular
Hepatic Adenomas, Familial

  • Hepatic Adenoma, Somatic

  • Familial Hepatic Adenoma

  • Familial Liver Cell Adenomas

  • Liver Cell Adenomas, Familial

  • Hepatic Adenomas Familial

  • HEPAF

  • Ha

  • Hepatocellular Adenomas

  • Hepatocellular Adenoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138097 α-NETA ≥98.0% Unkown
HY-P1844A Chemerin-9 (149-157) TFA 98.41% Unkown
HY-156460 CMKLR1 antagonist 1 Antagonist 99.70% Unkown
HY-174140 VU0514009 Antagonist 99.53% Unkown
HY-P1844 Chemerin-9 (149-157) 99.57% Unkown
HY-RS02860 CMKLR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174139 CMKLR1 antagonist 2 Antagonist / Unkown
HY-RS16979 Cmklr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23422 Cmklr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CMKLR1 VGNC VGNC:60999
Macaca mulatta CMKLR1 VGNC VGNC:99920
Bos taurus CMKLR1 VGNC VGNC:52753
Canis familiaris CMKLR1 VGNC VGNC:39378
Rattus norvegicus CMKLR1 RGD RGD:69359
Mus musculus CMKLR1 MGD MGI:109603
Others CMKLR1 NCBI