CLEC4C Antibody (YA1174)
(Synonyms: CLEC4C; BDCA2, CLECSF11, CLECSF7, DLEC, HECL; UNQ9361/PRO34150; C-type lectin domain family 4 member C; CD303; Blood dendritic cell antigen 2 (BDCA-2); C-type lectin superfamily member 7; Dendritic lectin)CLEC4C Antibody (YA1174) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLEC4C.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.293.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|
| Dilution Ratio | 1:100-1:200 |
Product Details
CLEC4C Antibody (YA1174) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CLEC4C.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 25 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 25 kDa
Recombinant protein of human CLEC4C
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.293.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CLEC4C is a Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells. Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium[1][2][3].
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Subcellular Localization
Cell membrane; Single-pass type II membrane protein
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Expression
Tissue_specificity:Expressed in plasmacytoid dendritic cells (PDCs) . Constitutively expressed in immature monocyte-derived dendritic cells (iMDDC) and is significantly down-regulated upon maturation with LPS but not with TNF-alpha -
Isoforms & Post-Translational Modification
Q8WTT0 has 2 isomers: Q8WTT0-1: 25038 Da (predicted); Q8WTT0-2: 21498 Da (predicted).
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Subunit
Homodimer
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SwissProt ID
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Synonyms
CLEC4C; BDCA2, CLECSF11, CLECSF7, DLEC, HECL; UNQ9361/PRO34150; C-type lectin domain family 4 member C; CD303; Blood dendritic cell antigen 2 (BDCA-2); C-type lectin superfamily member 7; Dendritic lectin
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Research Field
Tags & Cell Markers
Documentation
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