CLEC4C - C-type lectin domain family 4 member C Gene

Also Known as DLEC; HECL; BDCA2; CD303; BDCA-2; CLECSF7; CLECSF11; PRO34150

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 170482

About CLEC4C

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:7,729,383-7,749,541 (from NCBI)

This gene has 6 transcripts (splice variants), 747 orthologues and 14 paralogues. Biased expression in lymph node (RPKM 1.5), spleen (RPKM 0.9) and 6 other tissues.

Summary

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in dendritic cell function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CLEC4C Products (4)

mRNA Protein Name
NM_001371390.1 NP_001358319.1 C-type lectin domain family 4 member C isoform 1
NM_001371391.1 NP_001358320.1 C-type lectin domain family 4 member C isoform 3
NM_130441.3 NP_569708.1 C-type lectin domain family 4 member C isoform 1
NM_203503.2 NP_987099.1 C-type lectin domain family 4 member C isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC4C Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (102 - 208)

  • 0
  • 100
  • 200
  • 213 a.a.
Protein Preferred Names Protein Names

C-type lectin domain family 4 member C

  • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 11

Recombinant CLEC4C Proteins

Cat. No. Product Name Accession Purity
HY-P71679 CLEC4C Protein, Human (HEK293, His, Myc) Q8WTT0-1 (N45-I213) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72014 CLEC4C Protein, Human (His-SUMO) Q8WTT0-1 (N45-I213) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P78387 CLEC4C Protein, Human (Biotinylated, HEK293, His-Avi) Q8WTT0-1 (F46-I213) ≥ 90%, as determined by Bis-Tris PAGE.

CLEC4C Antibodies

Cat. No. Product Name Application Reactivity
HY-P81429 CLEC4C Antibody (YA1174) IHC-P Human
HY-P81429A CLEC4C Antibody (YA1174)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Cutaneous Lupus Erythematosus

  • Lupus Erythematosus, Cutaneous

  • Lupus Erythematosus Cutaneous
Cardiomyopathy, Dilated, 1c, With Or Without Left Ventricular Noncompaction

  • Left Ventricular Noncompaction 3

  • Dilated Cardiomyopathy 1c

  • CMD1C

  • Cardiomyopathy, Hypertrophic, 24

  • Dilated Cardiomyopathy With Left Ventricular Noncompaction

  • Cardiomyopathy, Dilated, 1c, With Or Without Lvnc

  • Cmdc1

  • Dilated Cardiomyopathy 1c With Or Without Left Ventricular Noncompaction

  • Cardiomyopathy, Dilated 1c, With Or Without Left Ventricular Non-Compaction

  • Cardiomyopathy Dilated With Left Ventricular Noncompaction

  • Cardiomyopathy, Familial Hypertrophic 24

  • CMH24

  • Left Ventricular Non-Compaction 3

  • LVNC3

  • Cardiomyopathy, Dilated 1c

  • Familial Hypertrophic Cardiomyopathy 24

  • Cardiomyopathy, Dilated, 1c
Inflammatory Bowel Disease 23

  • IBD23
Pitt-Hopkins Syndrome

  • PTHS

  • Encephalopathy, Severe Epileptic, With Autonomic Dysfunction

  • Mental Retardation, Syndromal, With Intermittent Hyperventilation

  • Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea

  • Pitt Hopkins Syndrome

  • Phs

  • Encephalopathy Severe Epileptic With Autonomic Dysfunction
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02792 CLEC4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990373 Anti-CLEC4C Antibody / Unkown
HY-P990374 Anti-CLEC7A Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLEC4C MGD MGI:1917060
Rattus norvegicus CLEC4C RGD RGD:1359354
Macaca mulatta CLEC4C VGNC VGNC:99915
Others CLEC4C NCBI