CYP11A1 Antibody (YA7714)
(Synonyms: CYP11A, CYP11A1, CYPXIA1, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450(scc))CYP11A1 Antibody (YA7714) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CYP11A1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, IP, IF-Tissue
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:2000-8000 (Do not reacts with Human samples) | 1:200-800 | 1:200-500 | 1:50-200 |
Product Details
CYP11A1 Antibody (YA7714) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CYP11A1.
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Host Rabbit
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Clonality Recombinant
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 53/57 kDa;
KLH conjugated synthetic peptide derived from human CYP11A1
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CYP11A1 is an A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin)[1].
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Subcellular Localization
Mitochondrion inner membrane
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Expression
Induction: By 8-bromo cyclic AMP
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Isoforms & Post-Translational Modification
P05108 has two isomers: P05108-1: 60102 Da (predicted); P05108-2: 42152 Da (predicted).
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Subunit
Interacts with FDX1/adrenodoxin
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SwissProt ID
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Synonyms
CYP11A, CYP11A1, CYPXIA1, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450(scc)
Documentation
References
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