DAND5 Antibody (YA8419)
(Synonyms: CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE; GREM3; SP1)DAND5 Antibody (YA8419) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DAND5.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
ICC/IF, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
DAND5 Antibody (YA8419) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to DAND5.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 18 kDa
Human recombinant protein fragment corresponding to amino acids 23-189 of human DAND5 produced in E.coli.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DAND5 is an Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development. Antagonist of BMP and TGF-beta signaling. Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway. Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation. Once internalized by endothelial cells, may alter their redox and glycolytic balance[1].
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Subcellular Localization
Secreted
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Expression
Tissue_Specificity: Expressed in the retina, in inner segments of photoreceptors, at or close to the outer plexiform layer and in the ganglion cell layer (at protein level)
Induction: Down-regulation during the establishment of embryonic left-right axis could be due to translation repression, involving BICC1 and possibly DICER1, and/or transcript degradation, involving BICC1 and the CCR4-NOT complex. Attenuated DAND5 expression lifts repression of NODAL and defines leftness by induction of the left lateral plate mesoderm NODAL signaling cascade -
Isoforms & Post-Translational Modification
Q8N907: 189 amino acids, molecular weight 20180 Da.
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SwissProt ID
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Synonyms
CER2; CERL2; CKTSF1B3; COCO; CRL2; DANTE; GREM3; SP1
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