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Desmoglein 1 Antibody (YA2873)

(Synonyms: Desmoglein-1; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen; Cadherin family member 4; DSG1; CDHF4)
Customer Review

Based on 1 Customer Validation

Desmoglein 1 Antibody (YA2873) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmoglein 1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, ICC/IF

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for Desmoglein 1 Antibody (YA2873)
  • Desmoglein 1 Antibody (YA2873) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Related Products:
Top Publications Citing

Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:1000-1:2000 1:100-1:200 1:50-1:200

Product Details

Description

Desmoglein 1 Antibody (YA2873) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmoglein 1.

  • Host Rabbit
  • Clonality Recombinant,Monoclonal
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 114 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 114 kDa
Species Reactivity Database

Entrez Gene: 1828 Human ;

SwissProt: Q02413 Human ;

Immunogen

A synthesized peptide derived from human DSG1 aa1000-1049/1049.

Sensitivity

Endogenous

Purification

Affinity Chromatography

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for Desmoglein 1 Antibody (YA2873)
    Immunohistochemical analysis of paraffin-embedded human lung cancer using Desmoglein 1 antibody. The section was pre-treated using heat mediated antigen retrieval with EDTA (pH 9.0) for 14 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with TBST, and then probed with the primary antibody (HY-P83128, 1/200) for 30 minutes at room temperature. The detection was performed using Polymer HRP-conjugated Goat Anti-Mouse/Rabbit lgG(H&L) secondary antibody (HY-P83652). DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

Background

  • Function

    Desmoglein 1 component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion[1][2].

  • Subcellular Localization

    Cell membrane; Single-pass type I membrane protein; Cell junction, desmosome; Cytoplasm; Nucleus

  • Expression


    Tissue_specificity:Expressed in all suprabasal layers of the epidermis, with the highest expression seen in the granular layer (at protein level)

    Induction:Protein abundance is reduced via proteasomal degradation in response to P.gingivalis infection of gingival epithelial cells

  • Isoforms & Post-Translational Modification

    Q02413 has 2 isomers: Q02413-1: 113748 Da (predicted); Q02413-2: 42619 Da (predicted).

  • Subunit

    Binds to JUP/plakoglobin (PubMed:19759396). Interacts with PKP2 (PubMed:11790773). Interacts with DSC3; there is evidence to suggest that the interaction promotes cell-cell adhesion of keratinocytes (PubMed:19717567)

  • SwissProt ID

    Q02413

  • Gene ID
    1828 [NCBI]
  • Synonyms

    Desmoglein-1; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen; Cadherin family member 4; DSG1; CDHF4

  • Research Field

    Signal Transduction

Desmoglein 1 Antibody (YA2873) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Immunohistochemical analysis of paraffin-embedded human lung cancer using Desmoglein 1 antibody. The section was pre-treated using heat mediated antigen retrieval with EDTA (pH 9.0) for 14 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with TBST, and then probed with the primary antibody (HY-P83128, 1/200) for 30 minutes at room temperature. The detection was performed using Polymer HRP-conjugated Goat Anti-Mouse/Rabbit lgG(H&L) secondary antibody (HY-P83652). DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

  • Desmoglein 1 Antibody (YA2873) Product Image
    1/16
  • Experimental Validation Results for Desmoglein 1 Antibody (YA2873)
  • Desmoglein 1 Antibody (YA2873) Product Image
  • Experimental Validation Results for Desmoglein 1 Antibody (YA2873)
    1/1
    MedChemExpress Validation
     Immunohistochemical analysis of paraffin-embedded human lung cancer using Desmoglein 1 antibody. The section was pre-treated using heat mediated antigen retrieval with EDTA (pH 9.0) for 14 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with TBST, and then probed with the primary antibody (HY-P83128, 1/200) for 30 minutes at room temperature. The detection was performed using Polymer HRP-conjugated Goat Anti-Mouse/Rabbit lgG(H&L) secondary antibody (HY-P83652). DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.
  • Experimental Validation Results for Desmoglein 1 Antibody (YA2873)
  • Desmoglein 1 Antibody (YA2873) Product Image
    MedChemExpress Validation

    Immunohistochemical analysis of paraffin-embedded human lung cancer using Desmoglein 1 antibody. The section was pre-treated using heat mediated antigen retrieval with EDTA (pH 9.0) for 14 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with TBST, and then probed with the primary antibody (HY-P83128, 1/200) for 30 minutes at room temperature. The detection was performed using Polymer HRP-conjugated Goat Anti-Mouse/Rabbit lgG(H&L) secondary antibody (HY-P83652). DAB was used as the chromogen. Tissues were counterstained with hematoxylin and mounted with DPX.

  • Desmoglein 1 Antibody (YA2873) Product Image IHC-P