Desmoglein 1 Antibody (YA2873)

Cat. No.: HY-P83128: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Desmoglein 1 Antibody (YA2873) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmoglein 1.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

Desmoglein 1 Antibody (YA2873) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

Desmoglein 1 Antibody (YA2873) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmoglein 1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 114 kDa;

Observed band size: 114 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q02413

Gene ID

1828 [NCBI]

Immunogen

A synthesized peptide derived from human DSG1 aa1000-1049/1049.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:2000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200

Sensitivity	Endogenous	Purity	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Component of intercellular desmosome junctions (PubMed:34368962). Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion (PubMed:19717567)

Subcellular Localization：Cell membrane; Single-pass type I membrane protein; Cell junction, desmosome; Cytoplasm; Nucleus

Expression：
Tissue_specificity:Expressed in all suprabasal layers of the epidermis, with the highest expression seen in the granular layer (at protein level)

Induction:Protein abundance is reduced via proteasomal degradation in response to P.gingivalis infection of gingival epithelial cells

Isoforms & Post-Translational Modification：Q02413 has 2 isomers: Q02413-1: 113748 Da (predicted); Q02413-2: 42619 Da (predicted).

Subunit：Binds to JUP/plakoglobin (PubMed:19759396). Interacts with PKP2 (PubMed:11790773). Interacts with DSC3; there is evidence to suggest that the interaction promotes cell-cell adhesion of keratinocytes (PubMed:19717567)

Database

Entrez Gene: 1828 Human ;

SwissProt: Q02413 Human ;

OMIM: 148700 Human

Research Field

Signal Transduction

Synonyms

Desmoglein-1; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen; Cadherin family member 4; DSG1; CDHF4

Documentation

Select Batch:

Data Sheet (232 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/mda-mb-231-cell.html [Content Brief]

Desmoglein 1 Antibody (YA2873) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Country or Region *

Email Address *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Desmoglein 1 Antibody (YA2873)

Desmoglein 1 Antibody (YA2873) Featured Recommendations:

Product Detail

Background

Documentation

References

Desmoglein 1 Antibody (YA2873) Related Classifications

Your Recently Viewed Products:

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report