Desmoplakin Antibody (YA2379)
(Synonyms: Desmoplakin I; Desmoplakin II; DPI; DPII; DSP; KPPS2; PPKS2)
Based on 1 Customer Validation
Desmoplakin Antibody (YA2379) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmoplakin.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, FC
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Reactivity :
Human, Rat
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Formulation:
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
|
|---|---|---|---|
| Dilution Ratio | 1:1000-1:5000 | 1:500-1:1000 | 1:100-1:200 |
Product Details
Desmoplakin Antibody (YA2379) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Desmoplakin.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 270 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 332 kDa
A synthesized peptide derived from human Desmoplakin
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Desmoplakin is a Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance
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Subcellular Localization
Cell junction, desmosome; Cell membrane; Cytoplasm
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Expression
Tissue_specificity:Expressed in oral mucosa (at protein level) (PubMed:30479852) . Expressed in arrector pili muscle (at protein level) (PubMed:29034528) . Expressed in the heart in the heart (at protein level) (PubMed:18662195) ; Apparently an obligate constituent of all desmosomes; Resides predominantly in tissues and cells of stratified origin -
Isoforms & Post-Translational Modification
P15924 has 3 isomers: P15924-1: 331774 Da (predicted); P15924-2: 260119 Da (predicted); P15924-3: 278916 Da (predicted).
Phosphorylation at Ser-2849 increases association with intermediate filament cytokeratin, potentially facilitating interaction between desmosome junctions and intermediate filament architecture -
Subunit
Homodimer. Interacts with COL17A1 (via cytoplasmic region) (PubMed:12482924). Interacts with DSC2 (PubMed:21062920). Interacts with PKP2 (PubMed:11790773, PubMed:22781308). Interacts with PKP1 (PubMed:10852826, PubMed:11790773, PubMed:23444369). Interacts weakly with TMEM65
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SwissProt ID
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Synonyms
Desmoplakin I; Desmoplakin II; DPI; DPII; DSP; KPPS2; PPKS2
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Research Field
Signal Transduction
Documentation
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Data Sheet (232 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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User Guide for Antibodies (1077 KB)
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