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DLL4 Antibody (YA7088)(PBS only)

(Synonyms: UNQ1895/PRO4341, DLL4, Delta-like protein 4, Drosophila Delta homolog 4, Delta4)

DLL4 Antibody (YA7088) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DLL4.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG2b

  • Application:

    IHC-P, ELISA

  • Reactivity :

    Human

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • DLL4 Antibody (YA7088)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:200-1000 1:10000

Product Details

Description

DLL4 Antibody (YA7088) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DLL4.

  • Host Mouse
  • Species Reactivity
    Human
  • Calculated Molecular Weight Predicted band size: 74.6kDa;
Immunogen

Purified recombinant fragment of human DLL4 expressed in E. Coli.

Purification

affinity purified.

Conjugation

Non-conjugated

Isotype

IgG2b

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    DLL4 is involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate[1][2][3].

  • Subcellular Localization

    Cell membrane

  • Expression


    Tissue_Specificity: Expressed in vascular endothelium

  • Isoforms & Post-Translational Modification

    Q9NR61: 685 amino acids, molecular weight 74605 Da.

  • Subunit

    Interacts with NOTCH4

  • SwissProt ID

    Q9NR61

  • Synonyms

    UNQ1895/PRO4341, DLL4, Delta-like protein 4, Drosophila Delta homolog 4, Delta4

DLL4 Antibody (YA7088)(PBS only) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • DLL4 Antibody (YA7088)(PBS only) Product Image