DnaJC3 Antibody
(Synonyms: P58IPK, PRKRI, DNAJC3, DnaJ homolog subfamily C member 3, Endoplasmic reticulum DNA J domain-containing protein 6, Protein kinase inhibitor of 58 kDa, ER-resident protein ERdj6, ERdj6, Protein kinase inhibitor p58)DnaJC3 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to DnaJC3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
DnaJC3 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to DnaJC3.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
Synthetic peptide corresponding to the center region of human DnaJC3.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
DnaJC3 is involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity
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Subcellular Localization
Endoplasmic reticulum
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Expression
Tissue_Specificity: Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
Induction: Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and THAP12. -
Isoforms & Post-Translational Modification
DnaJC3 has an amino acid length of 504, molecular weight is 57580 Da.DnaJC3 的氨基酸个数为 504 个，分子量为 57580 Da。
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Subunit
Interacts with EIF2AK4/GCN2; this interaction occurs under endoplasmic reticulum (ER) stress, hypothermic and amino acid starving stress conditions and inhibits EIF2AK4/GCN2 kinase activity.
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SwissProt ID
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Synonyms
P58IPK, PRKRI, DNAJC3, DnaJ homolog subfamily C member 3, Endoplasmic reticulum DNA J domain-containing protein 6, Protein kinase inhibitor of 58 kDa, ER-resident protein ERdj6, ERdj6, Protein kinase inhibitor p58
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