EMC1 Antibody (YA7247)(PBS only)
(Synonyms: KIAA0090, PSEC0263, EMC1, ER membrane protein complex subunit 1)EMC1 Antibody (YA7247) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to EMC1.
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Host:
Mouse
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Isotype:
IgG
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Application:
IHC-P, IHC-F, IF-Tissue, ICC/IF, ELISA
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Formulation:
Supplied in PBS, pH 7.4.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:100-500 | 1:100-500 | 1:100-500 | 1:100-500 | 1:5000-10000 |
Product Details
EMC1 Antibody (YA7247) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to EMC1.
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Host Mouse
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Calculated Molecular Weight Predicted band size: 107 kDa;
KLH conjugated synthetic peptide derived from human EMC1
affinity purified by Protein A
Non-conjugated
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
EMC1 is a Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)[1][2][3][4][5].
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Subcellular Localization
Endoplasmic reticulum membrane
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Isoforms & Post-Translational Modification
Q8N766 has four isomers: Q8N766-1: 111759 Da (predicted); Q8N766-2: 111631 Da (predicted); Q8N766-3: 111688 Da (predicted); Q8N766-4: 109421 Da (predicted).
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Subunit
Component of the ER membrane protein complex (EMC)
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SwissProt ID
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Synonyms
KIAA0090, PSEC0263, EMC1, ER membrane protein complex subunit 1
Documentation
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