ENTPD5 Antibody (YA2218)
(Synonyms: CD39L4; Entpd5; mNTPase; NTPDase 5; PCPH)ENTPD5 Antibody (YA2218) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ENTPD5.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
ENTPD5 Antibody (YA2218) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ENTPD5.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 48 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 48 kDa
Entrez Gene: 957 Human ; 12499 Mouse ; 314312 Rat
SwissProt: O75356 Human ; Q9WUZ9 Mouse ; Q6P6S9 Rat
OMIM: 603162 Human
A synthesized peptide derived from human ENTPD5 aa100-150/428.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ENTPD5 hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP. In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER[1][2].
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Subcellular Localization
Endoplasmic reticulum; Secreted
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Expression
Tissue_specificity:Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues
Induction:Up-regulated in cell lines and primary tumor samples with active AKT1 -
Subunit
Monomer; active form (PubMed:12508121). Homodimer; disulfide-linked. Homodimers are enzymatically inactive
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SwissProt ID
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Synonyms
CD39L4; Entpd5; mNTPase; NTPDase 5; PCPH
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Research Field
Epigenetics and Nuclear Signaling
Documentation
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