ENTPD5 - ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Gene

Homo sapiens

Also known as PCPH; CD39L4; NTPDase-5

Gene ID: 957 | Gene type: protein coding

About ENTPD5

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,955,329-74,019,288 (from NCBI)

This gene has 8 transcripts (splice variants), 275 orthologues and 7 paralogues. Broad expression in liver (RPKM 43.1), colon (RPKM 29.4) and 18 other tissues.

Summary

The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]

ENTPD5 Products(14)

mRNA	Protein	Name
NM_001249.5	NP_001240.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321984.2	NP_001308913.1	nucleoside diphosphate phosphatase ENTPD5 isoform 2 precursor
NM_001321985.3	NP_001308914.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321986.3	NP_001308915.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321987.3	NP_001308916.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321988.3	NP_001308917.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001330189.2	NP_001317118.1	nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor
NM_001382256.1	NP_001369185.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001382257.1	NP_001369186.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001382258.1	NP_001369187.1	nucleoside diphosphate phosphatase ENTPD5 isoform 4 precursor
NM_001382259.1	NP_001369188.1	nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor
NM_001382260.1	NP_001369189.1	nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor
NM_001382262.1	NP_001369191.1	nucleoside diphosphate phosphatase ENTPD5 isoform 5 precursor
NM_001382263.1	NP_001369192.1	nucleoside diphosphate phosphatase ENTPD5 isoform 6 precursor

ENTPD5 Protein Structure

GDA1_CD39

0
100
200
300
400
428 a.a.

Protein Preferred Names

Protein Names

nucleoside diphosphate phosphatase ENTPD5

CD39 antigen-like 4

Recombinant ENTPD5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76905	ENTPD5 Protein, Human (sf9, His)	O75356 (M1-H428)	≥95%

Related Diseases

Diseases

Alias

Coenzyme Q10 Deficiency, Primary, 6

Familial Steroid-Resistant Nephrotic Syndrome With Sensorineural Deafness	COQ10D6
Primary Coenzyme Q10 Deficiency 6	Familial Steroid-Resistant Nephrotic Syndrome With Sensorineural Hearing Loss
Srns With Sensorineural Deafness	Steroid-Resistant Nephrotic Syndrome With Sensorineural Deafness
Coenzyme Q10 Deficiency, Primary, Type 6

Lutembacher'S Syndrome

Lutembacher Syndrome

Lutembacher'S Anomaly

Scrapie

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04399	ENTPD5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ENTPD5	VGNC	VGNC:40384
Rattus norvegicus	ENTPD5	RGD	RGD:735219
Felis catus	ENTPD5	VGNC	VGNC:80977
Mus musculus	ENTPD5	MGD	MGI:1321385
Bos taurus	ENTPD5	VGNC	VGNC:28511
Others	ENTPD5	NCBI

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