ENTPD5 - ectonucleoside triphosphate diphosphohydrolase 5 (inactive) Gene

Also Known as PCPH; CD39L4; NTPDase-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 957

About ENTPD5

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,955,329-74,019,288 (from NCBI)

This gene has 8 transcripts (splice variants), 275 orthologues and 7 paralogues. Broad expression in liver (RPKM 43.1), colon (RPKM 29.4) and 18 other tissues.

Summary

The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. [provided by RefSeq, Jan 2009]

ENTPD5 Products (14)

mRNA	Protein	Name
NM_001249.5	NP_001240.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321984.2	NP_001308913.1	nucleoside diphosphate phosphatase ENTPD5 isoform 2 precursor
NM_001321985.3	NP_001308914.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321986.3	NP_001308915.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321987.3	NP_001308916.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001321988.3	NP_001308917.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001330189.2	NP_001317118.1	nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor
NM_001382256.1	NP_001369185.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001382257.1	NP_001369186.1	nucleoside diphosphate phosphatase ENTPD5 isoform 1 precursor
NM_001382258.1	NP_001369187.1	nucleoside diphosphate phosphatase ENTPD5 isoform 4 precursor
NM_001382259.1	NP_001369188.1	nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor
NM_001382260.1	NP_001369189.1	nucleoside diphosphate phosphatase ENTPD5 isoform 3 precursor
NM_001382262.1	NP_001369191.1	nucleoside diphosphate phosphatase ENTPD5 isoform 5 precursor
NM_001382263.1	NP_001369192.1	nucleoside diphosphate phosphatase ENTPD5 isoform 6 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP phosphatase activity	IDA IDA: Inferred from direct assay	10400613	GOA
enables CDP phosphatase activity	IDA IDA: Inferred from direct assay	10400613	GOA
enables GDP phosphatase activity	IDA IDA: Inferred from direct assay	10400613	GOA
enables IDP phosphatase activity	IDA IDA: Inferred from direct assay	15698960	GOA
enables UDP phosphatase activity	IDA IDA: Inferred from direct assay	10400613	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	15698960	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	10400613	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENTPD5 Protein Structure

GDA1_CD39

0
100
200
300
400
428 a.a.

Protein Preferred Names	Protein Names
nucleoside diphosphate phosphatase ENTPD5	CD39 antigen-like 4

ENTPD5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ENTPD5	O75356	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	ENTPD5	O75356	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	ENTPD5	O75356	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	ENTPD5	O75356	MXI1	Homo sapiens	P50539	Y2H Array	25416956
Intra	ENTPD5	O75356	MXI1	Homo sapiens	P50539	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ENTPD5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76905	ENTPD5 Protein, Human (sf9, His)	O75356 (V21-H428)	≥ 90%, as determined by reducing SDS-PAGE.

ENTPD5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82473	ENTPD5 Antibody (YA2218)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Coenzyme Q10 Deficiency, Primary, 6	Familial Steroid-Resistant Nephrotic Syndrome With Sensorineural Deafness COQ10D6 Primary Coenzyme Q10 Deficiency 6 Familial Steroid-Resistant Nephrotic Syndrome With Sensorineural Hearing Loss Srns With Sensorineural Deafness Steroid-Resistant Nephrotic Syndrome With Sensorineural Deafness Coenzyme Q10 Deficiency, Primary, Type 6
Lutembacher'S Syndrome	Lutembacher Syndrome Lutembacher'S Anomaly
Scrapie
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04399	ENTPD5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19255	Entpd5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25744	Entpd5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ENTPD5	VGNC	VGNC:40384
Rattus norvegicus	ENTPD5	RGD	RGD:735219
Felis catus	ENTPD5	VGNC	VGNC:80977
Mus musculus	ENTPD5	MGD	MGI:1321385
Bos taurus	ENTPD5	VGNC	VGNC:28511
Others	ENTPD5	NCBI