FATE1 Antibody (YA8377)

Cat. No.: HY-P88693: Data Sheet User Guide for Antibodies
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FATE1 Antibody (YA8377) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FATE1.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

FATE1 Antibody (YA8377) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FATE1.

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 20.5 kDa

Species Reactivity

Human

SwissProt ID

Q969F0

Immunogen

Full length human recombinant protein of human FATE1 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849)

Subcellular Localization：Mitochondrion,Mitochondrion outer membrane,Endoplasmic reticulum membrane

Expression：
Tissue_Specificity: Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919)

Isoforms & Post-Translational Modification：Q969F0: 183 amino acids, molecular weight 20712 Da.

Subunit：Interacts with BIK and RNF183 (PubMed:26567849)

Synonyms

CT43; FATE

Documentation

User Guide for Antibodies (1077 KB)