FATE1 Antibody (YA8377)
(Synonyms: CT43; FATE)FATE1 Antibody (YA8377) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FATE1.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
FATE1 Antibody (YA8377) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to FATE1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 20.5 kDa
Full length human recombinant protein of human FATE1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FATE1 is involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling[1][2].
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Subcellular Localization
Mitochondrion,Mitochondrion outer membrane,Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Testis-specific in fetus (aged from 6 to 11 weeks). In adult, expressed predominantly in testis, with some expression in lung, heart, kidney, adrenal gland and whole brain (PubMed:11694338). Highly expressed in certain types of cancer tissues such as hepatocellular carcinoma, colon and gastric cancer. Weakly expressed in normal pancreas (PubMed:12865919) -
Isoforms & Post-Translational Modification
Q969F0: 183 amino acids, molecular weight 20712 Da.
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Subunit
Interacts with BIK and RNF183 (PubMed:26567849)
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SwissProt ID
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Synonyms
CT43; FATE
Documentation
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