FGF-2 Antibody (YA8853)
(Synonyms: FGF2; FGFB; Fibroblast growth factor 2; FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2)
Based on 1 Customer Validation
FGF-2 Antibody (YA8853) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FGF-2.
-
Host:
Mouse
-
Isotype:
IgG1
-
Application:
WB, ICC/IF, ELISA
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in 1.0 ml of PBS with 0.1% sodium azide and 0.1% gelatin.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
|
|---|---|---|---|
| Dilution Ratio | 1:100-1:1000 | 1:50-500 | 1:30-1:3000 |
Product Details
FGF-2 Antibody (YA8853) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FGF-2.
-
Host Mouse
-
Clonality Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 18/22/24 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 31 kDa
Human FGF-2
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in 1.0 ml of PBS with 0.1% sodium azide and 0.1% gelatin.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
-
Shipping
Shipping with blue ice.
Background
-
Function
FGF-2 acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis. Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation[1][2][3][4][5][6][7].
-
Subcellular Localization
Secreted; Nucleus
-
Expression
Tissue_specificity:It is expressed in granulosa cells and cumulus cells. It is expressed in hepatocellular carcinoma cells, but not in non-cancerous liver tissue. -
Isoforms & Post-Translational Modification
P09038 has 4 isomers: P09038-4: 30770 Da (predicted); P09038-1: 22623 Da (predicted); P09038-2: 17254 Da (predicted); P09038-3: 21203 Da (predicted).
Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion;Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing -
Subunit
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3 (PubMed:18669637). Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling (PubMed:28302677). Interacts with SNORC (via the extracellular domain) (By similarity). Interacts with glypican GPC3 (By similarity)
-
SwissProt ID
-
Synonyms
FGF2; FGFB; Fibroblast growth factor 2; FGF-2; Basic fibroblast growth factor; bFGF; Heparin-binding growth factor 2; HBGF-2
Documentation
Powered by Bioz
