FOXC1 Antibody (YA9691)
(Synonyms: ARA, FKH L7, FKHL 7, FKHL7, Forkhead (Drosophila) like 7, Forkhead box C1, Forkhead box protein C1, Forkhead drosophila homolog like 7, Forkhead like 7, Forkhead related activator 3)FOXC1 Antibody (YA9691) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to FOXC1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF, IHC-P
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|---|
| Dilution Ratio | 1:2000 | 1:100 | 1:500 |
Product Details
FOXC1 Antibody (YA9691) is a Rabbit-derived and non-conjugated IgG Recombinant,Monoclonal antibody, targeting to FOXC1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 57 kDa;
Recombinant protein of human FOXC1 (aa 254-553).
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FOXC1 is a transcription factors belonging to FOXC family. FOXC1 is an essential component in embryonic development of brain, eye and bone. FOXC1 knock-out mice die at birth with hydrocephalus, eye defects, and multiple skeletal abnormalities. FOXC1 is recently identified as a critical regulator for the niche formation of haematopoietic stem and progenitor cells, as well as hair follicle stem cells. Elevated expression of FOXC1 occur in a variety of cancers such as breast carcinoma, hepatocellular carcinomas, lymphoma and so on. FOXC1 promotes cancers through mediating cell proliferation, metastasis, epithelial–mesenchymal transition (EMT), angiogenesis and lymphangiogenesis[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Expressed in keratinocytes of epidermis and hair follicle (PubMed:27907090) . Expressed strongly in microvascular invasion (MVI) formation, basal-like breast cancer (BLBC) and hepatocellular tumors (PubMed:20406990, PubMed:22991501) . Expressed in breast cancers (at protein level) (PubMed:26565916) . Expressed in hematopoietic cells (PubMed:8499623)
Induction:Up-regulated during the progression of epidermal keratinocyte differentiation (at protein level) (PubMed:27907090) . Up-regulated upon calcium-mediated keratinocyte differentiation (PubMed:27907090) . Up-regulated by transforming growth factor TGFB1 (PubMed:12408963) -
Subunit
Monomer. Interacts with C1QBP (PubMed:18676636). Interacts (via N-terminus) with GLI2 (via C-terminal internal region); this interaction is direct and increases GLI2 DNA-binding and transcriptional activity through a smoothened (SMO)-independent Hedgehog (Hh) signaling pathway (PubMed:26565916). Interacts (via C-terminus domain) with PITX2 isoform 3 (via homeobox domain) (PubMed:16449236). Interacts with FLNA and PBX1 (PubMed:15684392)
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SwissProt ID
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Synonyms
ARA, FKH L7, FKHL 7, FKHL7, Forkhead (Drosophila) like 7, Forkhead box C1, Forkhead box protein C1, Forkhead drosophila homolog like 7, Forkhead like 7, Forkhead related activator 3
Documentation
References
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