FOXC1 Antibody (YA9788)
(Synonyms: FKHL7, FREAC3, FOXC1, Forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FREAC-3)FOXC1 Antibody (YA9788) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to FOXC1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, FC, IP
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in TBS(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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FC
FC: Flow Cytometry
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1000 | 1:200-1000 | 1:200-500 | 1:20-50 |
Product Details
FOXC1 Antibody (YA9788) is a Rabbit-derived and non-conjugated IgG Monoclonal antibody, targeting to FOXC1.
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Host Rabbit
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 75 kDa;
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 57 kDa
Recombinant protein of human FOXC1
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in TBS(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FOXC1 is a transcription factors belonging to FOXC family. FOXC1 is an essential component in embryonic development of brain, eye and bone. FOXC1 knock-out mice die at birth with hydrocephalus, eye defects, and multiple skeletal abnormalities. FOXC1 is recently identified as a critical regulator for the niche formation of haematopoietic stem and progenitor cells, as well as hair follicle stem cells. Elevated expression of FOXC1 occur in a variety of cancers such as breast carcinoma, hepatocellular carcinomas, lymphoma and so on. FOXC1 promotes cancers through mediating cell proliferation, metastasis, epithelial–mesenchymal transition (EMT), angiogenesis and lymphangiogenesis[1].
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:Expressed in keratinocytes of epidermis and hair follicle (PubMed:27907090) . Expressed strongly in microvascular invasion (MVI) formation, basal-like breast cancer (BLBC) and hepatocellular tumors (PubMed:20406990, PubMed:22991501) . Expressed in breast cancers (at protein level) (PubMed:26565916) . Expressed in hematopoietic cells (PubMed:8499623)
Induction:Up-regulated during the progression of epidermal keratinocyte differentiation (at protein level) (PubMed:27907090) . Up-regulated upon calcium-mediated keratinocyte differentiation (PubMed:27907090) . Up-regulated by transforming growth factor TGFB1 (PubMed:12408963) -
Subunit
Monomer. Interacts with C1QBP (PubMed:18676636). Interacts (via N-terminus) with GLI2 (via C-terminal internal region); this interaction is direct and increases GLI2 DNA-binding and transcriptional activity through a smoothened (SMO)-independent Hedgehog (Hh) signaling pathway (PubMed:26565916). Interacts (via C-terminus domain) with PITX2 isoform 3 (via homeobox domain) (PubMed:16449236). Interacts with FLNA and PBX1 (PubMed:15684392)
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SwissProt ID
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Synonyms
FKHL7, FREAC3, FOXC1, Forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3, FREAC-3
Documentation
References
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