FoxP3 Antibody (YA4866)
(Synonyms: FOXP3; IPEX; JM2; Forkhead box protein P3; Scurfin)FoxP3 Antibody (YA4866) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FoxP3.
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Host:
Mouse
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Application:
WB, IHC-P, ICC/IF, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:200-1:1000 | 1:10000 |
Product Details
FoxP3 Antibody (YA4866) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to FoxP3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Calculated Molecular Weight Predicted band size: 47 kDa;
Purified recombinant fragment of human FoxP3 expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
FOXP3, so called scurfin, belongs to the forkhead box protein P (FOXP) family. FOXP3 is critically involved in differentiation and function of regulatory T cells or CD4+/CD25+ regulatory T (Treg) cells for cancer immunotherapy. FOXP3 modulates Treg development and functions by immune evasion of tumor cells through imbalance of immunoediting and immunosurveillance in some cancers. FOXP3 is associated with IL-17, RUNX1, STAT3, NF-κB, FOXO3 and other cofactors such as EOS (Ikzf4), interferon regulatory factor 4 (IRF4), special AT-rich sequence-binding protein-1 (SATB1) and GATA1.
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Subcellular Localization
Nucleus; Cytoplasm
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Expression
Induction: Down-regulated in regulatory T-cells (Treg) during inflammation. Up-regulated by FOXO3
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Isoforms & Post-Translational Modification
FOXP3 has four isomers: Q9BZS1-1: 47244 Da (predicted); Q9BZS1-2: 43410 Da (predicted); Q9BZS1-3: 49843 Da (predicted); Q9BZS1-4: 44407 Da (predicted).
Polyubiquitinated, leading to its proteasomal degradation in regulatory T-cells (Treg) which is mediated by STUB1 in a HSPA1A/B-dependent manner. -
Subunit
Homodimer
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SwissProt ID
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Synonyms
FOXP3; IPEX; JM2; Forkhead box protein P3; Scurfin
Documentation
[1]. Kim JH, et al. Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression. Mol Cancer. 2019 Dec 9;18(1):180. [Content Brief]
[2]. Co M, et al. FOXP transcription factors in vertebrate brain development, function, and disorders. Wiley Interdiscip Rev Dev Biol. 2020 Sep;9(5):e375. [Content Brief]
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