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FRA1 Antibody (YA7587)

(Synonyms: FRA1, FOSL1, Fos-related antigen 1, FRA-1)

FRA1 Antibody (YA7587) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to FRA1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, IHC-P, ICC/IF, ELISA

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Conjugation:
    Non-conjugated
  • FRA1 Antibody (YA7587) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
IHC-P Info
IHC-P: Immunohistochemistry-Paraffin
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:1000-1:4000 1:2000-1:10000 1:200-1:1000 1:5000-1:20000

Product Details

Description

FRA1 Antibody (YA7587) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to FRA1.

  • Host Rabbit
  • Clonality Monoclonal,Recombinant
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 40 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 29 kDa
Immunogen

The exact sequence is proprietary to MCE.

Sensitivity

Endogenous

Purification

Protein A affinity purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

  • Appearance

    Solution

  • Formulation

    Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    FRA1, a member of the FOS family, as a critical transcription factor during acinar de-differentiation to ADM. FRA1 depletion leads to resistance to ADM and PanIN formation after induction of acute pancreatitis. Mechanistically, FRA1 serves a protective role in acinar cells by preventing cell death and aiding in the progression of the ADM-PanIN-carcinoma continuum[1].

  • Subcellular Localization

    Nucleus

  • Isoforms & Post-Translational Modification

    FRA1 has 2 isomers: P15407-1: 29413 Da (predicted); P15407-2: 17560 Da (predicted).

  • Subunit

    Heterodimer (By similarity)

  • SwissProt ID

    P15407

  • Synonyms

    FRA1, FOSL1, Fos-related antigen 1, FRA-1

References

[1]. Li AL, et al. FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia. Dev Cell. 2024 Nov 18;59(22):3025-3042.e7. [Content Brief]

FRA1 Antibody (YA7587) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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