Galectin 9 Antibody (YA1127)(PBS only)

Cat. No.: HY-P81382A: Ficha de datos User Guide for Antibodies
FAQs
Technical Support

Galectin 9 Antibody (YA1127) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Galectin 9.

Para uso exclusivo en investigación. No vendemos a pacientes.

Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

* Seleccione Cantidad antes de agregar artículos.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

Galectin 9 Antibody (YA1127) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Galectin 9.

Host

Rabbit

Peso molecular

Predicted band size: 40 kDa;

Observed band size: 40 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

O00182

Gene ID

3965 [NCBI]

Immunogen

A synthesized peptide derived from human Galectin-9

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Pureza	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:16116184, PubMed:24465902). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:16116184, PubMed:25754930). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity); Acts as an eosinophil chemoattractant (PubMed:9642261). It also inhibits angiogenesis (PubMed:24333696). Suppresses IFNG production by natural killer cells (By similarity)

Subcellular Localization：Cytoplasm; Nucleus; Secreted; Secreted; Secreted

Expression：
Tissue_specificity:It is expressed in peripheral blood leukocytes and lymphoid tissues. It is also expressed in the lungs, liver, breast, and kidneys, with higher expression levels in tumor endothelial cells than in normal endothelial cells (protein level) (PubMed:24333696) . It is also expressed in the trophoblast cells of the decidua and placenta during pregnancy (protein level) (PubMed:23242525, PubMed:25578313) . Isomer 2 is the most abundant isomer expressed in endothelial cells (PubMed:24333696) . Upon endothelial cell activation, the expression of isomer 2 decreases, while the expression of isomers 3 and 5 increases (PubMed:24333696) . Isomer 4 is decreased in pathological pregnancies (PubMed:23242525) .

Induction:By toll-like receptor ligands zymosan (TLR2 ligand) , polyinosinic:polycytidylic acid (poly I:C) (TLR3 ligand) and lipopolysaccharides (LPS) (TLR4 ligand) and by pro-inflammatory cytokines IFNG, TNFA, IL1A and IL1B in mesenchymal stromal cells (PubMed:23817958) . By IFNG in macrophages (PubMed:20209097) . Up-regulated in dendritic cells following infection with dengue virus (PubMed:25754930) . Up-regulated in Kupffer cells following infection with hepatitis C virus (PubMed:20209097) . Up-regulated in plasma following infection with HIV-1 (PubMed:24786365)

Isoforms & Post-Translational Modification：O00182 has 6 isomers: O00182-1: 39518 Da (predicted); O00182-2: 35888 Da (predicted); O00182-3: 34691 Da (predicted); O00182-4: 26777 Da (predicted); O00182-5: 25579 Da (predicted); O00182-6: 38321 Da (predicted).

Subunit：Monomer

Research Field

Cell Biology

Synonyms

galectin 9; HUAT; LGALS9A

Documentación

User Guide for Antibodies (1077 KB)