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LGALS9 - galectin 9 Gene

Also Known as HUAT; LGALS9A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3965

About LGALS9

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:27,631,188-27,649,560 (from NCBI)

This gene has 16 transcripts (splice variants), 353 orthologues and 16 paralogues. Broad expression in spleen (RPKM 33.5), stomach (RPKM 28.4) and 23 other tissues.

Summary

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin's disease tissue and might participate in the interaction between the H&RS cells with their surrounding cells and might thus play a role in the pathogenesis of this disease and/or its associated immunodeficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

LGALS9 Products (3)

mRNA	Protein	Name
NM_001330163.2	NP_001317092.1	galectin-9 isoform 3
NM_002308.4	NP_002299.2	galectin-9 isoform short
NM_009587.3	NP_033665.1	galectin-9 isoform long

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables carbohydrate binding	IDA IDA: Inferred from direct assay	18977853	GOA
enables disaccharide binding	IMP IMP: Inferred from mutant phenotype	16116184	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	21670307	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	16116184	GOA
involved in cellular response to type II interferon	IDA IDA: Inferred from direct assay	23817958	GOA
involved in cellular response to virus	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in female pregnancy	IDA IDA: Inferred from direct assay	23242525	GOA
involved in inflammatory response	IDA IDA: Inferred from direct assay	23817958	GOA
involved in maternal process involved in female pregnancy	IDA IDA: Inferred from direct assay	25578313	GOA
NOT involved in mature conventional dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in natural killer cell tolerance induction	IMP IMP: Inferred from mutant phenotype	25578313	GOA
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	20209097	GOA
involved in negative regulation of activated T cell proliferation	IMP IMP: Inferred from mutant phenotype	23817958	GOA
involved in negative regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	23408620	GOA
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	25578313	GOA
involved in negative regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	24465902	GOA
involved in negative regulation of natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	23408620	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	25578313	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	23408620	GOA
involved in p38MAPK cascade	IDA IDA: Inferred from direct assay	16116184	GOA
involved in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response	IDA IDA: Inferred from direct assay	20209097	GOA
involved in positive regulation of CD4-positive, alpha-beta T cell proliferation	IDA IDA: Inferred from direct assay	16116184	GOA
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24465902	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IDA IDA: Inferred from direct assay	16116184	GOA
involved in positive regulation of activated T cell autonomous cell death	IDA IDA: Inferred from direct assay	20209097	GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	24465902	GOA
involved in positive regulation of dendritic cell apoptotic process	IDA IDA: Inferred from direct assay	16116184	GOA
involved in positive regulation of dendritic cell chemotaxis	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in positive regulation of dendritic cell differentiation	IMP IMP: Inferred from mutant phenotype	16116184	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	16116184	GOA
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	20209097	GOA
involved in positive regulation of interleukin-10 production	IDA IDA: Inferred from direct assay	16116184	GOA
involved in positive regulation of interleukin-12 production	IMP IMP: Inferred from mutant phenotype	16116184	GOA
involved in positive regulation of interleukin-13 production	IDA IDA: Inferred from direct assay	20209097	GOA
involved in positive regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	20209097	GOA
involved in positive regulation of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	25578313	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	24465902	GOA
involved in positive regulation of interleukin-8 production	IMP IMP: Inferred from mutant phenotype	24465902	GOA
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	24465902	GOA
involved in positive regulation of non-canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	25754930	GOA
involved in positive regulation of transforming growth factor beta production	IDA IDA: Inferred from direct assay	20209097	GOA
involved in positive regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	20209097	GOA
involved in positive regulation of type II interferon production	IDA IDA: Inferred from direct assay	20209097	GOA
involved in positive regulation of viral entry into host cell	IDA IDA: Inferred from direct assay	21670307	GOA
NOT involved in regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	16116184	GOA
NOT involved in regulation of interleukin-5 production	IDA IDA: Inferred from direct assay	16116184	GOA
NOT involved in regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	24465902	GOA
involved in response to interleukin-1	IDA IDA: Inferred from direct assay	23817958	GOA
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	25578313	GOA
NOT involved in toll-like receptor 2 signaling pathway	IDA IDA: Inferred from direct assay	16116184	GOA
NOT involved in toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	16116184	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23242525	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	20209097	GOA
located in nucleus	IDA IDA: Inferred from direct assay	23242525	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGALS9 Protein Structure

Gal-bind_lectin

0
100
200
300
355 a.a.

Protein Preferred Names	Protein Names
galectin-9	ecalectin

Recombinant LGALS9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70535	Galectin-9/LGALS9 Protein, Human (HEK293, His)	O00182-2 (M1-T323)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70696	Galectin-9/LGALS9 Protein, Human (GST)	O00182-2 (M1-T323)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700082AF	Animal-Free Galectin-9/LGALS9 Protein, Human (His)	O00182-2 (A2-T323)	≥ 95%, as determined by reducing SDS-PAGE.

LGALS9 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81382	Galectin 9 Antibody (YA1127)	IHC-P	Human
HY-P81382A	Galectin 9 Antibody (YA1127)(PBS only)	IHC-P	Human
HY-P85876	Galectin-9 Antibody (YA5568)	WB, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Patulous Eustachian Tube	Pet
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS23307	Lgals9 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07610	LGALS9 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07611	LGALS9B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16866	Lgals9 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992366	HFB200901	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LGALS9	RGD	RGD:3005
Mus musculus	LGALS9	MGD	MGI:109496
Others	LGALS9	NCBI