Galectin-9 Antibody (YA5568)
Galectin-9 Antibody (YA5568) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Galectin-9.
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Host:
Mouse
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Isotype:
IgG
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Application:
WB, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:100-500 | 1:1000-5000 |
Product Details
Galectin-9 Antibody (YA5568) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Galectin-9.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 37 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 39 kDa
Synthesized peptide derived from human Galectin-9 AA range: 1-100
Protein G
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Galectin-9 binds galactosides. Has high affinity for the Forssman pentasaccharide. Ligand for HAVCR2/TIM3. Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death. Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth. Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration. Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function. Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation. Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection. Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells. Inhibits degranulation and induces apoptosis of mast cells. Induces maturation and migration of dendritic cells. Inhibits natural killer (NK) cell function. Can transform NK cell phenotype from peripheral to decidual during pregnancy. Astrocyte derived galectin-9 enhances microglial TNF production. May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion. Highly selective to the anion urate; Acts as an eosinophil chemoattractant. It also inhibits angiogenesis. Suppresses IFNG production by natural killer cells[1][2][3][4][5][6][7][8][9][10][11][12].
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Subcellular Localization
Cytoplasm; Nucleus; Secreted; Secreted; Secreted
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Expression
Tissue_specificity:It is expressed in peripheral blood leukocytes and lymphoid tissues. It is also expressed in the lungs, liver, breast, and kidneys, with higher expression levels in tumor endothelial cells than in normal endothelial cells (protein level) (PubMed:24333696) . It is also expressed in the trophoblast cells of the decidua and placenta during pregnancy (protein level) (PubMed:23242525, PubMed:25578313) . Isomer 2 is the most abundant isomer expressed in endothelial cells (PubMed:24333696) . Upon endothelial cell activation, the expression of isomer 2 decreases, while the expression of isomers 3 and 5 increases (PubMed:24333696) . Isomer 4 is decreased in pathological pregnancies (PubMed:23242525) .
Induction:By toll-like receptor ligands zymosan (TLR2 ligand) , polyinosinic:polycytidylic acid (poly I:C) (TLR3 ligand) and lipopolysaccharides (LPS) (TLR4 ligand) and by pro-inflammatory cytokines IFNG, TNFA, IL1A and IL1B in mesenchymal stromal cells (PubMed:23817958) . By IFNG in macrophages (PubMed:20209097) . Up-regulated in dendritic cells following infection with dengue virus (PubMed:25754930) . Up-regulated in Kupffer cells following infection with hepatitis C virus (PubMed:20209097) . Up-regulated in plasma following infection with HIV-1 (PubMed:24786365) -
Isoforms & Post-Translational Modification
O00182 has 6 isomers: O00182-1: 39518 Da (predicted); O00182-2: 35888 Da (predicted); O00182-3: 34691 Da (predicted); O00182-4: 26777 Da (predicted); O00182-5: 25579 Da (predicted); O00182-6: 38321 Da (predicted).
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Subunit
Monomer
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SwissProt ID
Documentation
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