GATA3 Antibody (YA4872)
(Synonyms: GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3)GATA3 Antibody (YA4872) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GATA3.
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Host:
Mouse
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Application:
WB, IHC-P, ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:10000 | 1:50-200 |
Product Details
GATA3 Antibody (YA4872) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to GATA3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 48 kDa;
Purified recombinant fragment of human GATA-3 expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GATA3 transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression. Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages
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Subcellular Localization
Nucleus
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Expression
Tissue_specificity:T cells and endothelial cells -
Isoforms & Post-Translational Modification
P23771 has 2 isomers: P23771-1: 47916 Da (predicted); P23771-2: 48045 Da (predicted).
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Subunit
Interacts with TBX21 ('Tyr-530' phosphorylated form)
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SwissProt ID
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Synonyms
GATA3; Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3
Documentation
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