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Cat. No.: HY-P88033

GLO1 Antibody (YA7718)

GLO1 Antibody (YA7718) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GLO1.

For research use only. We do not sell to patients.

Formulation:
Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications

Application	WB WB: Western Blot	FC FC: Flow Cytometry	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence
Dilution Ratio	1:500-2000	1:50-100	1:50-200

Description

GLO1 Antibody (YA7718) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to GLO1.

Host Rabbit
Clonality Recombinant
Species Reactivity
Human Predicted Reactivity: Mouse,Rat

Note: The predicted reactivity is for reference only and should not be considered a guarantee of product performance.
Observed Molecular Weight

Observed band size: 21 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 21 kDa

Immunogen

A synthesized peptide derived from human Lactoylglutathione lyase

Sensitivity

Endogenous

Purification

affinity purified by Protein A

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Appearance

Liquid
Formulation

Supplied in 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Function

GLO1 catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis^[1]^[2]^[3]^[4].
Isoforms & Post-Translational Modification

Q04760 has two isomers: Q04760-1: 20778 Da (predicted); Q04760-2: 19043 Da (predicted).
Glutathionylation at Cys-139 inhibits enzyme activity丨Phosphorylated at Thr-107 in the presence of CaMK2丨Exists in a nitric oxide (NO)-modified form
Subunit

Homodimer
SwissProt ID

Q04760