GPR126 Antibody
(Synonyms: DREG, GPR126, VIGR, ADGRG6, Adhesion G-protein coupled receptor G6, Developmentally regulated G-protein-coupled receptor, G-protein coupled receptor 126, Vascular inducible G protein-coupled receptor)GPR126 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GPR126.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:100-500 |
Product Details
GPR126 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GPR126.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 136 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 136 kDa
Synthetic peptide corresponding to the center region of human GPR126.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GPR126 is an Adhesion G protein-coupled receptor (aGPCR) for steroid hormones, such as progesterone and 17alpha-hydroxyprogesterone (17OHP). Involved in many biological processes, such as myelination, sprouting angiogenesis, placenta, ear and cartilage development (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG6 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Also able to couple to G(q) G proteins. Involved in myelination of the peripheral nervous system: required for differentiation of promyelinating Schwann cells and for normal myelination of axons. Also acts as a regulator of body length and bone mass. Acts as a regulator of blood-brain barrier formation in the central nervous system vie its association with LRP1 and ITGB1 (By similarity)[1][2][3][4].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.
Induction: Up-regulated by bacterial lipopolysaccharides (LPS) and thrombin, but not by other inflammatory stimuli in primary umbilical veins. -
Isoforms & Post-Translational Modification
GPR126 has 4 isoforms, Q86SQ4-1: amino acid length is 1221, molecular weight is 136695 Da (predicted); Q86SQ4-2: amino acid length is 1193, molecular weight is 133671 Da (predicted); Q86SQ4-3: amino acid length is 1250, molecular weight is 139901 Da (predicted); Q86SQ4-4: amino acid length is 1222, molecular weight is 136878 Da (predicted).
Proteolytically cleaved into 2 conserved sites: one in the GPS region of the GAIN-B domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS region occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor. -
Subunit
Heterodimer of 2 chains generated by proteolytic processing; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked (By similarity).
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SwissProt ID
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Synonyms
DREG, GPR126, VIGR, ADGRG6, Adhesion G-protein coupled receptor G6, Developmentally regulated G-protein-coupled receptor, G-protein coupled receptor 126, Vascular inducible G protein-coupled receptor
Documentation
[1]. An W, et al. Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. Proc Natl Acad Sci U S A. 2022 Apr 12;119(15):e2117004119. [Content Brief]
[2]. Yang Z, et al. Identification, structure, and agonist design of an androgen membrane receptor. Cell. 2025 Mar 20;188(6):1589-1604.e24. [Content Brief]
[3]. Mogha A, et al. Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation. J Neurosci. 2013 Nov 13;33(46):17976-85. [Content Brief]
[4]. Lettre G, et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet. 2008 May;40(5):584-91. [Content Brief]
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