GPR87 Antibody
(Synonyms: GPR95, FKSG78, GPR87, G-protein coupled receptor 87, G-protein coupled receptor 95)GPR87 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GPR87.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:100-500 |
Product Details
GPR87 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to GPR87.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 41 kDa
Synthetic peptide corresponding to the center region of human GPR87.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GPR87 is a Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Promotes the Hippo-YAP signaling pathway and thereby modulates glycolysis and oxidative stress production by the regulation of hexokinase-2/HK2[1][2][3].
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Subcellular Localization
Cell membrane
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Expression
Tissue_Specificity: Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung.
Induction: By expression of p53/TP53 and by DNA damage in a TP53-dependent manner. -
Isoforms & Post-Translational Modification
GPR87 has an amino acid length of 358, molecular weight is 41436 Da.GPR87 的氨基酸个数为 358 个，分子量为 41436 Da。
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SwissProt ID
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Synonyms
GPR95, FKSG78, GPR87, G-protein coupled receptor 87, G-protein coupled receptor 95
Documentation
[1]. Tabata K, et al. The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor. Biochem Biophys Res Commun. 2007 Nov 23;363(3):861-6. [Content Brief]
[2]. Zhang Y, et al. The G protein-coupled receptor 87 is necessary for p53-dependent cell survival in response to genotoxic stress. Cancer Res. 2009 Aug 1;69(15):6049-56. [Content Brief]
[3]. Cui X, et al. GPR87 promotes renal tubulointerstitial fibrosis by accelerating glycolysis and mitochondrial injury. Free Radic Biol Med. 2022 Aug 20;189:58-70. [Content Brief]
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