GRIK3 Antibody (YA4222)
(Synonyms: EAA5; GLR7; GLUR7; GluK3; GluR7a)GRIK3 Antibody (YA4222) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRIK3.
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Host:
Mouse
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Isotype:
IgG1
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Application:
ICC/IF, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
GRIK3 Antibody (YA4222) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GRIK3.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 104 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 104 kDa
Purified recombinant fragment of human GRIK3 (AA: extra 32-173) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
GRIK3 is an Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses[1].
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Subcellular Localization
Cell membrane; Multi-pass membrane protein; Postsynaptic cell membrane; Multi-pass membrane protein
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Subunit
Homotetramer, and heterotetramer with either GRIK4 or GRIK5. Can form functional heteromeric receptors with GRIK2. Interacts with PRKCABP. Interacts with NETO2
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SwissProt ID
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Synonyms
EAA5; GLR7; GLUR7; GluK3; GluR7a
Documentation
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