HAO1 Antibody (YA5420)
(Synonyms: Hydroxyacid oxidase 1; HAOX1; Glycolate oxidase; GOX)HAO1 Antibody (YA5420) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HAO1.
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Host:
Mouse
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Application:
WB, IHC-P, ICC/IF,
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Reactivity :
Mouse, Rat
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Formulation:
Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
|
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:200 | 1:50-300 |
Product Details
HAO1 Antibody (YA5420) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to HAO1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityMouse, Rat
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Observed Molecular WeightObserved band size: 41 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Recombinant Protein of HAO1
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Hydroxyacid oxidase 1 (HAO1) functions as a rate-limiting enzyme in oxalate biosynthesis, catalyzing glycolate oxidation to glyoxylate, which is subsequently converted to oxalate[1]. Mechanistically, HAO1 activity in alveolar epithelial cells triggers oxalate accumulation, which activates NADPH oxidase and induces neutrophil extracellular trap (NET) formation, promoting pre-metastatic niche establishment in the lung[1]. This HAO1-mediated oxalate accumulation also enhances metastatic breast cancer cell proliferation via MAPK signaling activation[1]. Compared with related oxidase isoforms, HAO1 exhibits tissue-specific upregulation in pulmonary alveolar epithelium during the pre-metastatic stage, distinct from baseline hepatic expression of other hydroxyacid oxidases[1]. Pharmacologic inhibition of HAO1 effectively reduces oxalate accumulation and attenuates lung metastasis, providing a potential experimental model for studying metabolic regulation of metastatic niches[1]. For experimental applications, targeting HAO1 can modulate TLR3-IRF3 signaling-induced metabolic reprogramming, linking innate immune activation with local metabolite-driven niche formation[1].
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Subcellular Localization
Peroxisome matrix
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Expression
Tissue_specificity:Highly expressed in liver -
Subunit
Homotetramer
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SwissProt ID
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Synonyms
Hydroxyacid oxidase 1; HAOX1; Glycolate oxidase; GOX
Documentation
References
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