HERPUD1 Antibody (YA7806)
(Synonyms: HERP; Mif1; SUP)HERPUD1 Antibody (YA7806) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HERPUD1.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF
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Reactivity :
Human, Rat, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 |
Product Details
HERPUD1 Antibody (YA7806) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to HERPUD1.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Rat, Mouse
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Calculated Molecular Weight Predicted band size: 43.4 kDa
Full length human recombinant protein of human HERPUD1 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HERPUD1 component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway[1][2][3].
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Subcellular Localization
Endoplasmic reticulum membrane
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Expression
Tissue_Specificity: Widely expressed; in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease
Induction: Up-regulated by endoplasmic reticulum stress and CREB3 -
Isoforms & Post-Translational Modification
Q15011 has four isomers: Q15011-1: 43720 Da (predicted); Q15011-2: 43592 Da (predicted); Q15011-3: 26220 Da (predicted); Q15011-4: 40851 Da (predicted).
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Subunit
Interacts with PSEN1 and PSEN2 (PubMed:11799129)
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SwissProt ID
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Synonyms
HERP; Mif1; SUP
Documentation
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