HGS Antibody (YA7763)
(Synonyms: HRS)HGS Antibody (YA7763) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HGS.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:100-250 |
Product Details
HGS Antibody (YA7763) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to HGS.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 86 kDa
Full length human recombinant protein of human HGS produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation
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Subcellular Localization
Cytoplasm,Early endosome membrane,Endosome, multivesicular body membrane
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Expression
Tissue_Specificity: Ubiquitous expression in adult and fetal tissues with higher expression in testis and peripheral blood leukocytes -
Isoforms & Post-Translational Modification
O14964 has two isomers: O14964-1: 86192 Da (predicted); O14964-2: 76376 Da (predicted).
Phosphorylated on Tyr-334丨Ubiquitinated (PubMed:25588945) -
Subunit
Component of the ESCRT-0 complex composed of STAM or STAM2 and HGS
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SwissProt ID
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Synonyms
HRS
Documentation
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