ICAM-1 Antibody (YA7375)
ICAM-1 Antibody (YA7375) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to ICAM-1.
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Host:
Rabbit
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Isotype:
IgG,Kappa
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Application:
WB, IHC-P, ICC/IF, IP, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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IP
IP: Immunoprecipitation
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|---|---|---|---|---|---|
| Dilution Ratio | 1:100-200 | 1:1000-5000 | 1:200-1000 | 1:5000-20000 | 1:50-200 |
Product Details
ICAM-1 Antibody (YA7375) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to ICAM-1.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 100 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 58 kDa
The exact sequence is proprietary to MCE.
Endogenous
Protein A affinity purified
Non-conjugated
Unmodified
IgG,Kappa
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ICAM-1 is an ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation|(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins|(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins|(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell
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Subcellular Localization
Membrane
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Expression
Induction: Up-regulated by coagulation factor Xa (F10) in atrial tissues (PubMed:24041930). Up-regulated in atrial tissues by rapid pacing resembling atrial fibrillation (PubMed:24041930)
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Isoforms & Post-Translational Modification
P05362: 532 amino acids, molecular weight 57825 Da.
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Subunit
Homodimer (Probable)
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SwissProt ID
Documentation
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