IL-11 Antibody (YA4912)
(Synonyms: IL11; Interleukin-11; IL-11; Adipogenesis inhibitory factor; AGIF; Oprelvekin)
Based on 1 Customer Validation
IL-11 Antibody (YA4912) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL-11.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, ICC/IF, IP, ELISA, IF-Tissue
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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IP
IP: Immunoprecipitation
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|---|
| Dilution Ratio | 1:200-1000 | 1:50-500 | 1:50-500 | 1-2μg per 100-500μg Total protein | 1:50-3000 |
Product Details
IL-11 Antibody (YA4912) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL-11.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 23 kDa
Purified recombinant fragment(aa 30-200) of human IL-11 expressed in E. Coli.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS(pH7.4) containing 0.1% gelatin and < 0.1% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at 2-8°C for 1 year, do not freeze.
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Shipping
Shipping with blue ice.
Background
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Function
IL-11 is a Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation. Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling'[1][2][3].
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Subcellular Localization
Secreted
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Isoforms & Post-Translational Modification
P20809 has 2 isomers: P20809-1: 21429 Da (predicted); P20809-2: 12994 Da (predicted).
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Subunit
Interacts with IL11RA to associate with IL6ST, giving rise to a multimeric signaling complex
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SwissProt ID
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Synonyms
IL11; Interleukin-11; IL-11; Adipogenesis inhibitory factor; AGIF; Oprelvekin
Documentation
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