IL-5 Antibody (YA4710)

Cat. No.: HY-P85018: Fiche technique User Guide for Antibodies
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IL-5 Antibody (YA4710) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL-5.

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Size	Stock	Quantité
20 μL	Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 μL	Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
100 μL	Obtenir un devis 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
250 μL	Obtenir un devis

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Description

Description

IL-5 Antibody (YA4710) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL-5.

Host

Mouse

Clonality

Monoclonal

Species Reactivity

Human

SwissProt ID

P05113

Gene ID

3567 [NCBI]

Immunogen

Purified recombinant Human IL-5

Application &
Dilution Ratio

Application	Dilution Ratio
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-100000

Pureté	affinity purified.	Conjugation	Non-conjugated
Modification	Unmodified

Appearance

Liquid

Formulation

Supplied in Phosphate-buffered solution.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Livraison

Shipping with blue ice.

Background

Function：Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB (PubMed:1495999, PubMed:22528658). Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (PubMed:7613138)

Subcellular Localization：Secreted

Expression：
Tissue_specificity:Present in peripheral blood mononuclear cells

Isoforms & Post-Translational Modification：P05113 has 2 isomers: P05113-1: 15238 Da (predicted); P05113-2: 13982 Da (predicted).

Subunit：Homodimer; disulfide-linked (PubMed:22528658, PubMed:8483502). Interacts with IL5RA (PubMed:1495999, PubMed:22153509). Interacts with CSF2RB (PubMed:1495999)

Synonyms

IL5; Interleukin-5; IL-5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF; IL-5 nanobody;

Documentation

User Guide for Antibodies (1077 KB)