IL16 Antibody (YA4913)

Cat. No.: HY-P85221: Data Sheet User Guide for Antibodies
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IL16 Antibody (YA4913) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL16.

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사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

IL16 Antibody (YA4913) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL16.

Host

Mouse

Clonality

Monoclonal

분자량

Predicted band size: 142 kDa;

Species Reactivity

Human

SwissProt ID

Q14005

Gene ID

3603 [NCBI]

Immunogen

Purified recombinant fragment of human IL-16 expressed in E. Coli.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1500
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-300
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:250-1:500

Sensitivity	Endogenous	Purity	affinity purified.
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2a

Appearance

Liquid

Formulation

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4; May act as a scaffolding protein that anchors ion channels in the membrane; Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells

Subcellular Localization：Secreted; Cytoplasm; Cytoplasm; Nucleus

Expression：
Tissue_specificity:Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation

Induction:Down-regulated in T-cells after TCR activation

Isoforms & Post-Translational Modification：Q14005 has 4 isomers: Q14005-1: 141752 Da (predicted); Q14005-2: 141681 Da (predicted); Q14005-3: 66646 Da (predicted); Q14005-4: 59345 Da (predicted).
Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16

Subunit：Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function.

Synonyms

IL16; Pro-interleukin-16

각종 서류

User Guide for Antibodies (1077 KB)