IL16 Antibody (YA4913)
(Synonyms: IL16; Pro-interleukin-16)IL16 Antibody (YA4913) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL16.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide
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Conjugation:
Non-conjugated
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:1000-1500 | 1:200-300 | 1:250-1:500 |
Product Details
IL16 Antibody (YA4913) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IL16.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 142 kDa;
Purified recombinant fragment of human IL-16 expressed in E. Coli.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
IL16 is an Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4; May act as a scaffolding protein that anchors ion channels in the membrane; Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells
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Subcellular Localization
Secreted; Cytoplasm; Cytoplasm; Nucleus
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Expression
Tissue_specificity:Expressed in hemopoietic tissues, such as resting T-cells, but undetectable during active T-cell proliferation
Induction:Down-regulated in T-cells after TCR activation -
Isoforms & Post-Translational Modification
Q14005 has 4 isomers: Q14005-1: 141752 Da (predicted); Q14005-2: 141681 Da (predicted); Q14005-3: 66646 Da (predicted); Q14005-4: 59345 Da (predicted).
Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16 -
Subunit
Homotetramer (Probable). According to PubMed:9699630, the formation of a homotetrameric protein complex is not required for the chemo-attractant function.
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SwissProt ID
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Synonyms
IL16; Pro-interleukin-16
Documentation
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