ITFG2 (MDS028) Antibody (YA8312)

Cat. No.: HY-P88628: Data Sheet User Guide for Antibodies
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ITFG2 (MDS028) Antibody (YA8312) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ITFG2 (MDS028).

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

ITFG2 (MDS028) Antibody (YA8312) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ITFG2 (MDS028).

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 49.1 kDa

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q969R8

Immunogen

Full length human recombinant protein of human ITFG2 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose

Subcellular Localization：Lysosome membrane

Isoforms & Post-Translational Modification：Q969R8 has two isomers: Q969R8-1: 49313 Da (predicted); Q969R8-2: 15974 Da (predicted).

Subunit：Part of the KICSTOR complex composed of KPTN, ITFG2, KICS2 and SZT2

Synonyms

MDS028

Documentation

User Guide for Antibodies (1077 KB)