ITFG2 (MDS028) Antibody (YA8312)
(Synonyms: MDS028)ITFG2 (MDS028) Antibody (YA8312) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ITFG2 (MDS028).
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Host:
Mouse
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Isotype:
IgG
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Application:
ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|
| Dilution Ratio | 1:100-250 | 1:100 |
Product Details
ITFG2 (MDS028) Antibody (YA8312) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ITFG2 (MDS028).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 49.1 kDa
Full length human recombinant protein of human ITFG2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
ITFG2 is an As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose
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Subcellular Localization
Lysosome membrane
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Isoforms & Post-Translational Modification
Q969R8 has two isomers: Q969R8-1: 49313 Da (predicted); Q969R8-2: 15974 Da (predicted).
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Subunit
Part of the KICSTOR complex composed of KPTN, ITFG2, KICS2 and SZT2
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SwissProt ID
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Synonyms
MDS028
Documentation
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