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Jagged 2 Antibody (YA2941)

(Synonyms: HJ2; JAG2; Jagged2; SER2; Syndactylism)
Customer Review

Based on 1 Customer Validation

Jagged 2 Antibody (YA2941) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Jagged 2.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB

  • Reactivity :

    Human, Mouse

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Conjugation:
    Non-conjugated
  • Experimental Validation Results for Jagged 2 Antibody (YA2941)
  • Jagged 2 Antibody (YA2941) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
Dilution Ratio 1:500-1:1000

Product Details

Description

Jagged 2 Antibody (YA2941) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Jagged 2.

  • Host Rabbit
  • Clonality Recombinant, Monoclonal
  • Species Reactivity
    Human, Mouse
  • Observed Molecular Weight
    Observed band size: 145 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 133 kDa
Species Reactivity Database
Immunogen

A synthesized peptide derived from human JAG2 aa25-89.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

RRID

AB_3105311

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Verification Images

  • Experimental Validation Results for Jagged 2 Antibody (YA2941)
    Western blot analysis of extracts from HUVEC(lane 2(20ug) and HUVEC(lane 3(40ug) using Jagged 2 Antibody (HY-P83196) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background

  • Function

    Jagged 2 is a Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development

  • Subcellular Localization

    Membrane; Single-pass type I membrane protein

  • Expression


    Tissue_specificity:Expressed in heart, placenta and skeletal muscle and to a lesser extent in pancreas. Very low expression in brain, lung, liver and kidney

  • Isoforms & Post-Translational Modification

    Q9Y219 has 2 isomers: Q9Y219-1: 133367 Da (predicted); Q9Y219-2: 129235 Da (predicted).

  • SwissProt ID

    Q9Y219

  • Gene ID
    3714 [NCBI]
  • Synonyms

    HJ2; JAG2; Jagged2; SER2; Syndactylism

  • Research Field

    Neuroscience

Jagged 2 Antibody (YA2941) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     Western blot analysis of extracts from HUVEC(lane 2(20ug) and HUVEC(lane 3(40ug) using Jagged 2 Antibody (HY-P83196) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • Jagged 2 Antibody (YA2941) Product Image
    1/16
  • Experimental Validation Results for Jagged 2 Antibody (YA2941)
  • Jagged 2 Antibody (YA2941) Product Image
  • Experimental Validation Results for Jagged 2 Antibody (YA2941)
    1/1
    MedChemExpress Validation
     Western blot analysis of extracts from HUVEC(lane 2(20ug) and HUVEC(lane 3(40ug) using Jagged 2 Antibody (HY-P83196) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.
  • Experimental Validation Results for Jagged 2 Antibody (YA2941)
  • Jagged 2 Antibody (YA2941) Product Image
    MedChemExpress Validation

    Western blot analysis of extracts from HUVEC(lane 2(20ug) and HUVEC(lane 3(40ug) using Jagged 2 Antibody (HY-P83196) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

  • Jagged 2 Antibody (YA2941) Product Image WB