KAT9 Antibody (YA3382)

Cat. No.: HY-P83637: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

KAT9 Antibody (YA3382) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KAT9.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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KAT9 Antibody (YA3382) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

KAT9 Antibody (YA3382) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to KAT9.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 62 kDa;

Observed band size: 62 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9H9T3

Gene ID

55140 [NCBI]

Immunogen

A synthesized peptide derived from human KAT9 / Elp3 aa1-547.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:1000-1:2000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:200
IP IP: Immunoprecipitation	1:50

Sensitivity	Endogenous	Purity	Affinity Chromatography
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29415125). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase (PubMed:29415125). Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337). Required for acetylation of GJA1 in the developing cerebral cortex (By similarity)

Subcellular Localization：Cytoplasm; Nucleus; Nucleus; Cytoplasm; Nucleus

Expression：
Tissue_specificity:Expressed in the cerebellum and spinal motor neurons

Isoforms & Post-Translational Modification：Q9H9T3 has 4 isomers: Q9H9T3-1: 62259 Da (predicted); Q9H9T3-2: 60648 Da (predicted); Q9H9T3-4: 49405 Da (predicted); Q9H9T3-5: 52202 Da (predicted).
Tyrosine-phosphorylated; phosphorylation on Tyr-202 does not affect elongator complex integrity or ELP3 protein stability (PubMed:31341009). Also serine/threonine-phosphorylated (PubMed:31341009)

Subunit：Component of the elongator complex which consists of ELP1, ELP2, ELP3, ELP4, ELP5 and ELP6. ELP1, ELP2 and ELP3 form the elongator core complex (PubMed:11714725, PubMed:11818576, PubMed:19185337, PubMed:22854966, PubMed:25960406). Interacts with alpha-tubulin (PubMed:19185337)

Database

Entrez Gene: 55140 Human ; 74195 Mouse ; 361058 Rat

SwissProt: Q9H9T3 Human ; Q9CZX0 Mouse ;

OMIM: 105400 Human

Research Field

Epigenetics and Nuclear Signaling

Synonyms

Elongation protein 3 homolog; elp3; hELP3; Kat9

Documentation

Select Batch:

Data Sheet (232 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

KAT9 Antibody (YA3382) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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KAT9 Antibody (YA3382)

KAT9 Antibody (YA3382) Featured Recommendations:

Product Detail

Background

Documentation

KAT9 Antibody (YA3382) Related Classifications

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