KBTBD7 Antibody (YA8117)
(Synonyms: DKFZp434E2318)KBTBD7 Antibody (YA8117) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KBTBD7.
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Host:
Mouse
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Isotype:
IgG2b
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Application:
ICC/IF
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Reactivity :
Human, Dog, Rat, Monkey, Mouse
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|
| Dilution Ratio | 1:100-250 |
Product Details
KBTBD7 Antibody (YA8117) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to KBTBD7.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Dog, Rat, Monkey, Mouse
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Calculated Molecular Weight Predicted band size: 77.0 kDa
Full length human recombinant protein of human KBTBD7 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2b
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KBTBD7 is an As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation. By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation. Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex[1].
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Subcellular Localization
Cytoplasm,Nucleus
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Isoforms & Post-Translational Modification
Q8WVZ9: 684 amino acids, molecular weight 77163 Da.
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Subunit
Core component of a BCR3 (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, also named Cul3-RING ubiquitin ligase complex CUL3(KBTBD6/7), composed of CUL3, RBX1, KBTBD6 and KBTBD7 (PubMed:25684205)
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SwissProt ID
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Synonyms
DKFZp434E2318
Documentation
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