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Cat. No.: HY-P83126

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Kir2.1 Antibody (YA2871)

Name: Kir2.1 Antibody (YA2871)
Brand: MedChemExpress
SKU: HY-P83126
Price: 146.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: KCNJ2; ATFB9; HHBIRK1; IRK1; KIR2.1; LQT7; HIRK1; IRK-1; HHIRK1; SQT3)

Customer Review

Based on 1 Customer Validation

Kir2.1 Antibody (YA2871) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Kir2.1.

For research use only. We do not sell to patients.

Host:
Rabbit
Isotype:
IgG
Application:
WB, IHC-P, ICC/IF
Reactivity :
Human, Mouse, Rat

Formulation:
Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Conjugation:
Non-conjugated

Size

Price

Stock

Quantity

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Applications
Product Details
Product Properties
- Appearance
- Formulation
- Concentration
- Storage & Stability
- Shipping
Background
Documentation
References
Help & FAQs
Classifications
Bioz

Applications

Application	WB WB: Western Blot	IHC-P IHC-P: Immunohistochemistry-Paraffin	ICC/IF ICC/IF: Immunocytochemistry/ Immunofluorescence
Dilution Ratio	1:500-1:1000	1:50-1:100	1:50-1:200

Product Details

Description

Kir2.1 Antibody (YA2871) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Kir2.1.

Host Rabbit
Clonality Recombinant,Monoclonal
Species Reactivity
Human, Mouse, Rat
Observed Molecular Weight

Observed band size: 53 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Calculated Molecular Weight Predicted band size: 48 kDa

Species Reactivity Database

Entrez Gene: 3759 Human ; 16518 Mouse ; 29712 Rat

SwissProt: P63252 Human ; P35561 Mouse ; Q64273 Rat

OMIM: 170390 Human

Immunogen

A synthesized peptide derived from human Kir21 aa100-150/427.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG

Product Properties

Appearance

Solution
Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Concentration

Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.

Background

Function

Kir2.1 is an Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues^[1]^[2]^[3]^[4]^[5].
Subcellular Localization

Cell membrane; Multi-pass membrane protein; Cell membrane, sarcolemma, T-tubule
Expression

Tissue_specificity:Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain
Subunit

Homotetramer (PubMed:36149965, PubMed:16571646). Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3 (PubMed:12032359). Can form heteromeric channels with Kir2.6/KCNJ18 (PubMed:21209095). Associates, via its PDZ-recognition domain, with a complex containing LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 (By similarity)
SwissProt ID

P63252
Gene ID

3759 [NCBI]
Synonyms

KCNJ2; ATFB9; HHBIRK1; IRK1; KIR2.1; LQT7; HIRK1; IRK-1; HHIRK1; SQT3
Research Field

Neuroscience

Documentation

Select Batch:

Data Sheet (261 KB)
SDS (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
User Guide for Antibodies (1077 KB)

References

[1]. Fernandes CAH, et al. Cryo-electron microscopy unveils unique structural features of the human Kir2.1 channel. Sci Adv. 2022 Sep 23;8(38):eabq8489. [Content Brief]

[2]. Wood LS, et al. Cloning and functional expression of a human gene, hIRK1, encoding the heart inward rectifier K+-channel. Gene. 1995 Oct 3;163(2):313-7. [Content Brief]

[3]. Tare M, et al. Inwardly rectifying whole cell potassium current in human blood eosinophils. J Physiol. 1998 Jan 15;506 ( Pt 2)(Pt 2):303-18. [Content Brief]

[4]. Raab-Graham KF, et al. Molecular cloning and expression of a human heart inward rectifier potassium channel. Neuroreport. 1994 Dec 20;5(18):2501-5. [Content Brief]

[5]. Ashen MD, et al. Inward rectifier K+ channel from human heart and brain: cloning and stable expression in a human cell line. Am J Physiol. 1995 Jan;268(1 Pt 2):H506-11. [Content Brief]