2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. Kir2.1 Antibody (YA2871)

Kir2.1 Antibody (YA2871) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Kir2.1.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

Kir2.1 Antibody (YA2871) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Kir2.1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Molecular Weight
Predicted band size: 48 kDa;
Observed band size: 53 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human Kir21 aa100-150/427.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
IHC-P
IHC-P: Immunohistochemistry-Paraffin
1:50-1:100
ICC/IF
ICC/IF: Immunocytochemistry/Immunofluorescence
1:50-1:200
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:36149965, PubMed:7590287, PubMed:9490857). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:7590287, PubMed:7696590). The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:9490857). Can be blocked by extracellular barium or cesium (PubMed:7590287, PubMed:7696590). Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (PubMed:7590287, PubMed:7696590, PubMed:7840300)
Subcellular Localization：Cell membrane; Multi-pass membrane protein; Cell membrane, sarcolemma, T-tubule
Expression：
Tissue_specificity:Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain
Subunit：Homotetramer (PubMed:36149965, PubMed:16571646). Homomultimeric and heteromultimeric association with KCNJ4/Kir2.3 (PubMed:12032359). Can form heteromeric channels with Kir2.6/KCNJ18 (PubMed:21209095). Associates, via its PDZ-recognition domain, with a complex containing LIN7A, LIN7B, LIN7C, DLG1, CASK and APBA1 (By similarity)
Database

Entrez Gene: 3759 Human ; 16518 Mouse ; 29712 Rat

SwissProt: P63252 Human ; P35561 Mouse ; Q64273 Rat

OMIM: 170390 Human

Research Field

Neuroscience
Synonyms
KCNJ2; ATFB9; HHBIRK1; IRK1; KIR2.1; LQT7; HIRK1; IRK-1; HHIRK1; SQT3
Documentation
SDS (252 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

Kir2.1 Antibody (YA2871) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Kir2.1 Antibody (YA2871)
Cat. No.:
HY-P83126
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