Kir4.1 Antibody
(Synonyms: ATP-sensitive inward rectifier potassium channel 10, Inward rectifier K(+) channel Kir4.1, Kcnj10)Kir4.1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Kir4.1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|---|
| Dilution Ratio | 1:1000-2000 | 1:100-200 | 1:50-200 |
Product Details
Kir4.1 Antibody is a Rabbit-derived and non-conjugated IgG Polyclonal antibody, targeting to Kir4.1.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman, Mouse, Rat
Synthetic peptide corresponding to the center region of human Kir4.1.
Endogenous
affinity purified.
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH 7.4), containing 30% glycerol, and 0.01% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Kir4.1 may be responsible for potassium buffering action of glial cells in the brain (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules[1][2].
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Subcellular Localization
Membrane; Basolateral cell membrane
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Expression
Tissue_Specificity: Expressed in kidney (at protein level). In the nephron, expressed in the distal convoluted tubule, the connecting tubule, the collecting duct and cortical thick ascending limbs. -
Isoforms & Post-Translational Modification
Kir4.
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Subunit
Homotetramer (By similarity).
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SwissProt ID
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Synonyms
ATP-sensitive inward rectifier potassium channel 10, Inward rectifier K(+) channel Kir4.1, Kcnj10
Documentation
[1]. Shuck ME, et al. Cloning and characterization of two K+ inward rectifier (Kir) 1.1 potassium channel homologs from human kidney (Kir1.2 and Kir1.3). J Biol Chem. 1997 Jan 3;272(1):586-93. [Content Brief]
[2]. Tanemoto M, et al. Mislocalization of K+ channels causes the renal salt wasting in EAST/SeSAME syndrome. FEBS Lett. 2014 Mar 18;588(6):899-905. [Content Brief]
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