KLHL21 Antibody (YA4936)

Art. -Nr.: HY-P85244: Data Sheet User Guide for Antibodies
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Technical Support

KLHL21 Antibody (YA4936) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLHL21.

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Größe		Verfügbarkeit
50 μL		Angebot einholen
100 μL		Angebot einholen

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Beschreibung
Verweise

Beschreibung

KLHL21 Antibody (YA4936) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLHL21.

Host

Mouse

Clonality

Monoclonal

Molekulargewicht

Predicted band size: 66kDa;

Species Reactivity

Human

SwissProt ID

Q9UJP4

Gene ID

9903 [NCBI]

Immunogen

Purified recombinant fragment of human KLHL21 expressed in E. Coli. The exact sequence is proprietary to MCE.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Sensitivity	Endogenous	Reinheit	affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in Ascitic fluid containing 0.03% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Versand

Shipping with blue ice.

Background

Function：Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome

Subcellular Localization：Cytoplasm, cytoskeleton, spindle

Isoforms & Post-Translational Modification：Q9UJP4 has 2 isomers: Q9UJP4-1: 66617 Da (predicted); Q9UJP4-2: 60378 Da (predicted).

Subunit：Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1

Synonyms

KLHL21; KIAA0469; Kelch-like protein 21

Dokumentation

User Guide for Antibodies (1077 KB)

Verweise

[1]. /biology-dictionary/mcf7-cell.html [Content Brief]