KLHL21 Antibody (YA4936)
(Synonyms: KLHL21; KIAA0469; Kelch-like protein 21)KLHL21 Antibody (YA4936) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLHL21.
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Host:
Mouse
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Isotype:
IgG1
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Application:
IHC-P, ELISA
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Reactivity :
Human
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Formulation:
Supplied in Ascitic fluid containing 0.03% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:10000 |
Product Details
KLHL21 Antibody (YA4936) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to KLHL21.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 66kDa;
Purified recombinant fragment of human KLHL21 expressed in E. Coli. The exact sequence is proprietary to MCE.
Endogenous
affinity purified
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in Ascitic fluid containing 0.03% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
KLHL21 is a Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome
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Subcellular Localization
Cytoplasm, cytoskeleton, spindle
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Isoforms & Post-Translational Modification
Q9UJP4 has 2 isomers: Q9UJP4-1: 66617 Da (predicted); Q9UJP4-2: 60378 Da (predicted).
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Subunit
Component of the BCR(KLHL21) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL21 and RBX1
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SwissProt ID
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Synonyms
KLHL21; KIAA0469; Kelch-like protein 21
Documentation
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