Lipocalin 2 Antibody (YA991)

製品番号: HY-P81284: データシート SDS COA User Guide for Antibodies
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Lipocalin 2 Antibody (YA991) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lipocalin 2.

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容量	価格（税別）	在庫状況	数量
無料サンプル		今すぐ申し込む
10 μL	$84	在庫あり	Estimated Time of Arrival: December 31
50 μL	$222	在庫あり	Estimated Time of Arrival: December 31
100 μL	$360	在庫あり	Estimated Time of Arrival: December 31
250 μL		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

おすすめ:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
説明

製品説明

Lipocalin 2 Antibody (YA991) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lipocalin 2.

Host

Mouse

Clonality

Monoclonal

分子量

Predicted band size: 23 kDa;

Observed band size: 23 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Rat

SwissProt ID

P80188

Gene ID

3934 [NCBI]

Immunogen

Purified recombinant human NGAL protein expressed in E.coli.

Application &
Dilution Ratio

Application	Dilution Ratio
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:10000

Sensitivity	Endogenous	純度	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG1

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

輸送条件

Shipping with blue ice.

Background

Function：Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:20581821, PubMed:27780864). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin (PubMed:27780864). Can also bind siderophores from M.tuberculosis (PubMed:15642259, PubMed:21978368)

Subcellular Localization：Secreted; Cytoplasmic granule lumen; Cytoplasmic vesicle lumen

Expression：
Tissue_specificity:Detected in neutrophils (protein level) (PubMed:7683678, PubMed:8298140) . Expressed in bone marrow and tissues susceptible to microbial infection (PubMed:9339356) . Highly expressed in bone marrow, as well as in the uterus, prostate, salivary glands, stomach, appendix, colon, trachea, and lungs (PubMed:9339356) . Expressed in renal medullary tubules (PubMed:30418175) . Not detected in small intestine or peripheral blood leukocytes (PubMed:9339356) .

Induction:Expression is activated by the oncoprotein BCR-ABL; BCR-ABL misregulates expression via the JAK/STAT pathway and binding of STAT5A to the promoter (PubMed:19229297) . Induced by insulin (PubMed:30418175)

Isoforms & Post-Translational Modification：P80188 has 2 isomers: P80188-1: 22588 Da (predicted); P80188-2: 22457 Da (predicted).

Subunit：Monomer (PubMed:1281792, PubMed:7683678). Homodimer; disulfide-linked (PubMed:7683678). Heterodimer; disulfide-linked with MMP9 (PubMed:7683678)

RRID

AB_3103363

Database

Entrez Gene: 3934 Human ; 170496 Rat

SwissProt: P80188 Human ; P30152 Rat

OMIM: 600181 Human

Research Field

Immunology

Synonyms

LCN2; 24p3; MSFI; NGAL; Lipocalin-2; p25; Siderocalin; SV40 induced 24P3 protein; Uterocalin

ドキュメンテーション

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データシート (234 KB) SDS (251 KB)

COA (205 KB)

User Guide for Antibodies (1077 KB)