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Lipocalin 2 Antibody (YA991)

(Synonyms: LCN2; 24p3; MSFI; NGAL; Lipocalin-2; p25; Siderocalin; SV40 induced 24P3 protein; Uterocalin)
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Lipocalin 2 Antibody (YA991) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lipocalin 2.

For research use only. We do not sell to patients.
  • Host:

    Mouse

  • Isotype:

    IgG1

  • Application:

    ELISA

  • Reactivity :

    Human, Rat

  • Formulation:

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Conjugation:
    Non-conjugated
  • Lipocalin 2 Antibody (YA991) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Applications

Application
ELISA Info
ELISA: Enzyme Linked Immunosorbent Assay
Dilution Ratio 1:10000

Product Details

Description

Lipocalin 2 Antibody (YA991) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lipocalin 2.

  • Host Mouse
  • Clonality Monoclonal
  • Species Reactivity
    Human, Rat
  • Observed Molecular Weight
    Observed band size: 23 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 23 kDa
Species Reactivity Database
Immunogen

Purified recombinant human NGAL protein expressed in E.coli.

Sensitivity

Endogenous

Purification

Affinity Purified

Conjugation

Non-conjugated

Modification

Unmodified

Isotype

IgG1

RRID

AB_3103363

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.

  • Concentration

    Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Lipocalin 2 is an Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis[1][2][3][4][5].

  • Subcellular Localization

    Secreted; Cytoplasmic granule lumen; Cytoplasmic vesicle lumen

  • Expression


    Tissue_specificity:Detected in neutrophils (protein level) (PubMed:7683678, PubMed:8298140) . Expressed in bone marrow and tissues susceptible to microbial infection (PubMed:9339356) . Highly expressed in bone marrow, as well as in the uterus, prostate, salivary glands, stomach, appendix, colon, trachea, and lungs (PubMed:9339356) . Expressed in renal medullary tubules (PubMed:30418175) . Not detected in small intestine or peripheral blood leukocytes (PubMed:9339356) .

    Induction:Expression is activated by the oncoprotein BCR-ABL; BCR-ABL misregulates expression via the JAK/STAT pathway and binding of STAT5A to the promoter (PubMed:19229297) . Induced by insulin (PubMed:30418175)

  • Isoforms & Post-Translational Modification

    P80188 has 2 isomers: P80188-1: 22588 Da (predicted); P80188-2: 22457 Da (predicted).

  • Subunit

    Monomer (PubMed:1281792, PubMed:7683678). Homodimer; disulfide-linked (PubMed:7683678). Heterodimer; disulfide-linked with MMP9 (PubMed:7683678)

  • SwissProt ID

    P80188

  • Gene ID
    3934 [NCBI]
  • Synonyms

    LCN2; 24p3; MSFI; NGAL; Lipocalin-2; p25; Siderocalin; SV40 induced 24P3 protein; Uterocalin

  • Research Field

    Immunology

Lipocalin 2 Antibody (YA991) Related Classifications

MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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