LRRK2 Antibody (YA7371)
(Synonyms: PARK8, LRRK2, Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin)LRRK2 Antibody (YA7371) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to LRRK2.
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Host:
Rabbit
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Isotype:
IgG
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Application:
IHC-P, IHC-F, ELISA, IF-Tissue
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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IHC-F
IHC-F: Immunohistochemistry-Frozen
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IF-Tissue
IF-Tissue: Immunofluorescence-Tissue
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:1000-1:10000 | 1:200-500 | 1:200-1:1000 | 1:3000-1:50000 |
Product Details
LRRK2 Antibody (YA7371) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to LRRK2.
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Host Rabbit
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Clonality Monoclonal,Recombinant
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Species ReactivityHuman, Mouse, Rat
Recombinant protein of human LRRK2 (aa 1300-1600).
Endogenous
Protein A affinity purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS (pH7.4) containing 50% glycerol, 0.05% Proclin 300, 0.05%BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Leucine-rich repeat kinase 2 (LRRK2) is a ubiquitously expressed member of the ROCO protein family. LRRK2 is a complex, multidomain protein containing kinase and GTPase enzymatic activities and multiple protein-protein interaction domains. LRRK2 is the genetic cause of both familial and idiopathic Parkinson's disease (PD), and it is associated with neuronal death, vesicle trafficking, mitochondrial dysfunction, and inflammation. LRRK2 is a very large protein comprised of 2527 amino acids which has been determined to contain multiple functional domains, including armadillo (ARM), ankyrin-repeats (ANK), leucine-rich repeats (LRR), Ras of complex proteins (ROC), C-terminal of Roc (COR), MAPK-like kinase, and WD40 motifs. Mutations in LRRK2 represent a significant component of both sporadic and familial PD. Pathogenic mutations cluster in the enzymatic domains of LRRK2, and kinase activity seems to correlate with cytotoxicity, suggesting the possibility of kinase-based therapeutic strategies for LRRK2-associated PD. The best-characterized mutation to date, G2019S, leads to increased kinase activity, and mutations in the GTPase domain, such as R1441C and R1441G, have also been reported to influence kinase activity.
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Subcellular Localization
Cytoplasmic vesicle,Perikaryon,Golgi apparatus membrane,Cell projection, axon,Cell projection, dendrite,Endoplasmic reticulum membrane,Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane,Endosome,Lysosome,Mitochondrion outer membrane,Cytoplasm, cytoskeleton,Cytoplasmic vesicle, phagosome
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Expression
Tissue_Specificity: Expressed in pyramidal neurons in all cortical laminae of the visual cortex, in neurons of the substantia nigra pars compacta and caudate putamen (at protein level). Expressed in neutrophils (at protein level) (PubMed:29127255). Expressed in the brain. Expressed throughout the adult brain, but at a lower level than in heart and liver. Also expressed in placenta, lung, skeletal muscle, kidney and pancreas. In the brain, expressed in the cerebellum, cerebral cortex, medulla, spinal cord occipital pole, frontal lobe, temporal lobe and putamen. Expression is particularly high in brain dopaminoceptive areas -
Isoforms & Post-Translational Modification
Q5S007: 2527 amino acids, molecular weight 286103 Da.
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Subunit
Homodimer (PubMed:18230735, PubMed:22952686, PubMed:30635421, PubMed:38127736)
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SwissProt ID
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Synonyms
PARK8, LRRK2, Leucine-rich repeat serine/threonine-protein kinase 2, Dardarin
Documentation
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