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  4. Monoclonal Antibodies Recombinant Antibodies
  5. MADCAM1 Antibody (YA2744)

MADCAM1 Antibody (YA2744)

Cat. No.: HY-P82999
User Guide for Antibodies Technical Support

MADCAM1 Antibody (YA2744) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MADCAM1.

For research use only. We do not sell to patients.

Size Price Stock Quantity
20 μL Get quote 4 - 5 Weeks 3 - 4 Weeks 5 - 6 Weeks 4 - 5 weeks
50 μL Get quote 4 - 5 Weeks 3 - 4 Weeks 5 - 6 Weeks 4 - 5 weeks
100 μL Get quote 4 - 5 Weeks 3 - 4 Weeks 5 - 6 Weeks 4 - 5 weeks
250 μL   Get quote  
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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

MADCAM1 Antibody (YA2744) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MADCAM1.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 40 kDa;
Observed band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human MADCAM1 aa1-53/382.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding
Subcellular Localization：Membrane; Single-pass type I membrane protein
Expression：
Tissue_specificity:Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes
Isoforms & Post-Translational Modification：Q13477 has 4 isomers: Q13477-1: 40155 Da (predicted); Q13477-2: 28705 Da (predicted); Q13477-3: 31109 Da (predicted); Q13477-4: 21247 Da (predicted).
The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation
Subunit：Homodimer
Database

Entrez Gene: 8174 Human

SwissProt: Q13477 Human

OMIM: 102670 Human

Research Field

Cardiovascular
Synonyms
MACAM1; Madcam1
Documentation
User Guide for Antibodies (1077 KB)

MADCAM1 Antibody (YA2744) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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MADCAM1 Antibody (YA2744)
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