MADCAM1 Antibody (YA2744)
(Synonyms: MACAM1; Madcam1)MADCAM1 Antibody (YA2744) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MADCAM1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human
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Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
MADCAM1 Antibody (YA2744) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MADCAM1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 60 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 40 kDa
A synthesized peptide derived from human MADCAM1 aa1-53/382.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MADCAM1 cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding
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Subcellular Localization
Membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Highly expressed on high endothelial venules (HEV) and lamina propia venules found in the small intestine, and to a lesser extent in the colon and spleen. Very low levels of expression found in pancreas and brain. Not expressed in the thymus, prostate, ovaries, testis, heart, placenta, lung, liver, skeletal muscle, kidney or peripheral blood leukocytes -
Isoforms & Post-Translational Modification
Q13477 has 4 isomers: Q13477-1: 40155 Da (predicted); Q13477-2: 28705 Da (predicted); Q13477-3: 31109 Da (predicted); Q13477-4: 21247 Da (predicted).
The Ser/Thr-rich mucin-like domain may provide possible sites for O-glycosylation -
Subunit
Homodimer
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SwissProt ID
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Synonyms
MACAM1; Madcam1
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Research Field
Cardiovascular
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