MADCAM1 - mucosal vascular addressin cell adhesion molecule 1 Gene

Also Known as MACAM1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8174

About MADCAM1

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:496,486-505,343 (from NCBI)

This gene has 5 transcripts (splice variants) and 96 orthologues. Biased expression in appendix (RPKM 6.2), spleen (RPKM 4.9) and 6 other tissues.

Summary

The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 Integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

MADCAM1 Products (2)

mRNA Protein Name
NM_130760.3 NP_570116.2 mucosal addressin cell adhesion molecule 1 isoform a precursor
NM_130762.3 NP_570118.1 mucosal addressin cell adhesion molecule 1 isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables integrin binding involved in cell-matrix adhesion IDA
IDA: Inferred from direct assay
23986478 GOA
Biological Process GO Annotation Evidence References Source
involved in cell-matrix adhesion IDA
IDA: Inferred from direct assay
18308860 GOA
involved in heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
18308860 GOA
involved in integrin-mediated signaling pathway IDA
IDA: Inferred from direct assay
23986478 GOA
involved in leukocyte tethering or rolling IDA
IDA: Inferred from direct assay
18308860 GOA
involved in receptor clustering IDA
IDA: Inferred from direct assay
23986478 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MADCAM1 Protein Structure

Adhes-Ig_like

Adhes-Ig_like: Adhesion molecule, immunoglobulin-like (113 - 224)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
Protein Preferred Names Protein Names

mucosal addressin cell adhesion molecule 1

  • MAdCAM-1

Recombinant MADCAM1 Proteins

Cat. No. Product Name Accession Purity
HY-P71818 MAdCAM1 Protein, Human (P.pastoris, His-Myc) Q13477 (Q19-Q317) ≥ 90%, as determined by reducing SDS-PAGE.

MADCAM1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82999 MADCAM1 Antibody (YA2744) WB Human

Related Diseases

Diseases Alias
Colon Kaposi Sarcoma

  • Colonic Kaposi'S Sarcoma
Ileitis

  • Crohn'S Ileitis
Cholangitis, Primary Sclerosing

  • Primary Sclerosing Cholangitis

  • PSC

  • Sclerosing Cholangitis

  • Cholangitis, Sclerosing

  • Cholangitis Primary Sclerosing

  • Psc - [Primary Sclerosing Cholangitis]
Colitis
Cholangitis

  • Acute Cholangiolitis

  • Ascending Cholangitis

  • Cholangiolitis

  • Cholangitis Nos

  • Chronic Cholangiolitis

  • Hepatic Duct Inflammation

  • Acute Cholangitis

  • Bile Duct Inflammation
Type 1 Diabetes Mellitus 21

  • Diabetes Mellitus, Insulin-Dependent, 21

  • Iddm21

  • T1D21

  • Insulin-Dependent Diabetes Mellitus 21
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Lymphoma, Mucosa-Associated Lymphoid Type

  • Malt Lymphoma

  • Gastric Lymphoma, Primary

  • Lymphoma, Malt, Somatic

  • Mucosa-Associated Lymphoid Tissue Lymphoma

  • Extranodal Marginal Zone B-Cell Lymphoma

  • MALTOMA

  • Marginal Zone B-Cell Lymphoma

  • Mucosa-Associated Lymphatic Tissue Lymphoma

  • Primary Gastric Lymphoma

  • Gastric Lymphoma

  • Familial Primary Gastric Lymphoma
Progressive Multifocal Leukoencephalopathy

  • Pml

  • Leukoencephalopathy, Progressive Multifocal

  • Progressive Multifocal Leukoencephalitis

  • Leukoencephalopathy Progressive Multifocal

  • Pml - [Progressive Multifocal Leukoencephalopathy]
Listeria Meningitis

  • Meningitis, Listeria
Acquired Immunodeficiency Syndrome

  • Acquired Immune Deficiency Syndrome

  • AIDS

  • Acquired Immune Deficiency

  • Acquired Immunodeficiency

  • Acquired Immunodeficiency Due To Protein Loss
Ascending Cholangitis
Sclerosing Cholangitis

  • Fibrosing Cholangitis

  • Cholangitis, Sclerosing

  • Primary Sclerosing Cholangitis
Autoimmune Disease Of Gastrointestinal Tract
Gastroduodenal Crohn'S Disease

  • Upper Gi Crohn'S Disease
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99411 Ontamalimab 99.86% Phase 3

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159179 α4 integrin receptor antagonist 3 Inhibitor / Unkown
HY-171216 GW559090 Antagonist / Unkown
HY-177961 α4β7 Integrin-IN-1 Inhibitor / Unkown
HY-RS07952 MADCAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19091 Madcam1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25581 Madcam1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990203 Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) Inhibitor 99.08% Unkown
HY-P991807 Anti-Mouse MAdCAM-1 Antibody (MECA-89) Inhibitor / Unkown
HY-P990197 Anti-Mouse MAdCAM-1 Antibody (MECA-367) Inhibitor 96.72% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus MADCAM1 RGD RGD:3029
Canis familiaris MADCAM1 VGNC VGNC:42916
Felis catus MADCAM1 VGNC VGNC:68127
Mus musculus MADCAM1 MGD MGI:103579
Bos taurus MADCAM1 VGNC VGNC:31133
Others MADCAM1 NCBI