MAPRE2 (EB2) Antibody (YA7830)
(Synonyms: EB1; EB2; RP1)MAPRE2 (EB2) Antibody (YA7830) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MAPRE2 (EB2).
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF, FC
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Reactivity :
Human
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|
| Dilution Ratio | 1:150-500 | 1:100-250 | 1:100 |
Product Details
MAPRE2 (EB2) Antibody (YA7830) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MAPRE2 (EB2).
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Calculated Molecular Weight Predicted band size: 36.9 kDa
Full length human recombinant protein of human MAPRE2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
MAPRE2 is an Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability. Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation. Plays a role during oocyte meiosis by regulating microtubule dynamics. Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation. Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics[1][2][3].
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Subcellular Localization
Cytoplasm, cytoskeleton
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Expression
Tissue_Specificity: Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes -
Isoforms & Post-Translational Modification
Q15555 has 5 isomers: Q15555-1: 37031 Da (predicted); Q15555-2: 29091 Da (predicted); Q15555-3: 35741 Da (predicted); Q15555-5: 32236 Da (predicted); Q15555-4: 30691 Da (predicted).
Phosphorylated at Ser-236 by CK2 leading to enhanced cell adhesion (PubMed:23844040)丨Ubiquitinated in an ASB14-dependent manner; leading to proteasomal degradation -
Subunit
Interacts with DCTN1
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SwissProt ID
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Synonyms
EB1; EB2; RP1
Documentation
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