MAPRE2 (EB2) Antibody (YA7830)

Cat. No.: HY-P88146: Data Sheet User Guide for Antibodies
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MAPRE2 (EB2) Antibody (YA7830) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MAPRE2 (EB2).

For research use only. We do not sell to patients.

Size	Price	Stock
20 μL		Ask For Quote & Lead Time
50 μL		Ask For Quote & Lead Time
100 μL		Ask For Quote & Lead Time

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

MAPRE2 (EB2) Antibody (YA7830) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to MAPRE2 (EB2).

Host

Mouse

Clonality

Monoclonal

Molecular Weight

Predicted band size: 36.9 kDa

Species Reactivity

Human

SwissProt ID

Q15555

Immunogen

Full length human recombinant protein of human MAPRE2 produced in HEK293T cell.

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:150-500
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:100-250
FC FC: Flow Cytometry	1:100

Sensitivity	Endogenous	Purity	Affinity purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG2a

Appearance

Liquid

Formulation

Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (PubMed:27030108). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (PubMed:22373814). Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (PubMed:26527684)

Subcellular Localization：Cytoplasm, cytoskeleton

Expression：
Tissue_Specificity: Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes

Isoforms & Post-Translational Modification：Q15555 has 5 isomers: Q15555-1: 37031 Da (predicted); Q15555-2: 29091 Da (predicted); Q15555-3: 35741 Da (predicted); Q15555-5: 32236 Da (predicted); Q15555-4: 30691 Da (predicted).
Phosphorylated at Ser-236 by CK2 leading to enhanced cell adhesion (PubMed:23844040)丨Ubiquitinated in an ASB14-dependent manner; leading to proteasomal degradation

Subunit：Interacts with DCTN1

Synonyms

EB1; EB2; RP1

Documentation

User Guide for Antibodies (1077 KB)